Ian Stansfield

TL;DR: There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence in Candida albicans species.

TL;DR: In this article, it was shown that the TORs, two related phosphatidylinositol kinase homologues, are part of a novel signaling pathway that activates eIF-4E-dependent protein synthesis and prevent early G1 progression in response to nutrient availability.

TL;DR: It is proposed that Sup45p andSup35p interact to form a release factor complex in yeast and that Sup35p, which has GTP binding sequence motifs in its C‐terminal domain, provides the GTP hydrolytic activity which is a demonstrated requirement of the eukaryote translation termination reaction.

TL;DR: The genetic screen results and the mutant phenotypes are consistent with a role for domain 1 in stop codon recognition; the topology of this e RF1 domain, together with eRF1-stop codon complex modeling further supports the proposal that this domain may represent the site of stop codons binding itself.

TL;DR: Comparing the conservation of stress signalling molecules in diverse fungal species with their stress resistance revealed that in general, central components of the osmotic, oxidative and cell wall stress signalling pathways are relatively well conserved, whereas the sensors lying upstream and transcriptional regulators lying downstream of these modules have diverged significantly.