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Ie Ming Shih
Researcher at Johns Hopkins University
Publications - 401
Citations - 40438
Ie Ming Shih is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Ovarian cancer & Serous fluid. The author has an hindex of 97, co-authored 378 publications receiving 35329 citations. Previous affiliations of Ie Ming Shih include Howard Hughes Medical Institute & MedStar Washington Hospital Center.
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Top-down morphogenesis of colorectal tumors.
Ie Ming Shih,Tian Li Wang,Giovanni Traverso,Kathy Romans,Stanley R. Hamilton,Shmuel A. Ben-Sasson,Kenneth W. Kinzler,Bert Vogelstein +7 more
TL;DR: The results imply that development of adenomatous polyps proceeds through a top-down mechanism, as genetically altered cells in the superficial portions of the mucosae spread laterally and downward to form new crypts that first connect to preexisting normal crypts and eventually replace them.
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Are all pelvic (nonuterine) serous carcinomas of tubal origin
TL;DR: The findings, showing that nearly 60% of high-grade pelvic (nonuterine) serous carcinomas are associated with STICs, are consistent with the proposal that the fallopian tube is the source of a majority of these tumors.
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MicroRNA Expression and Identification of Putative miRNA Targets in Ovarian Cancer
Neetu Dahiya,Cheryl A. Sherman-Baust,Tian Li Wang,Ben Davidson,Ie Ming Shih,Yongqing Zhang,William H. Wood,Kevin G. Becker,Patrice J. Morin +8 more
TL;DR: Interestingly, there was little overlap between the predicted and the experimental targets or pathways, or between experimental targets/pathways obtained using different cell lines, highlighting the complexity of miRNA target selection.
Journal Article
Increased plasma DNA integrity in cancer patients
Brant G. Wang,Han Yao Huang,Yu Chi Chen,Robert E. Bristow,Keyanunoosh Kassauei,Chih Chien Cheng,Richard B.S. Roden,Lori J. Sokoll,Daniel W. Chan,Ie Ming Shih +9 more
TL;DR: The findings suggest that increased DNA integrity in plasma DNA is associated with cancer, and measurement of DNA integrity may provide a simple and inexpensive measure for cancer detection.
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Diverse tumorigenic pathways in ovarian serous carcinoma.
TL;DR: A dualistic model for ovarian serous carcinogenesis is proposed that involves a stepwise progression from SBT to noninvasive and then invasive MPSC and is characterized by rapid progression from the ovarian surface epithelium or inclusion cysts to a conventional (high-grade) serous cancers.