Ie Ming Shih

TL;DR: Results suggest that overexpression of Rsf-1, cyclin E and FASN occurs early in tumor progression, which is fundamental in understanding the molecular pathogenesis of high-grade serous carcinomas.

TL;DR: It is shown that NF-κB and STAT5 inhibitor could sensitize carboplatin-resistant cells and suggest that such inhibitors can be used to benefit patients with carboplati-resistant recurrent ovarian cancer.

TL;DR: This review will focus on advances with special emphasis on the pathogenesis of each specific form of GTD, which includes complete and partial hydatidiform mole, invasive mole, choriocarcinoma, placental site trophoblastic tumor, epithelioid trophoblast, and placental sites nodule.

TL;DR: A strategy to amplify and sequence long interspersed element-1 (LINE-1, L1) retrotransposon insertions selectively in the human genome, transposon insertion profiling by next-generation sequencing (TIPseq), and the development of a machine-learning–based computational pipeline, TIPseqHunter, to identify insertion sites with high precision and reliability.

TL;DR: Studies on autocrine and paracrine roles of growth factors in melanoma development and progression will require models that can account for the complex interactions between normal and malignant cells.