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Ie Ming Shih
Researcher at Johns Hopkins University
Publications - 401
Citations - 40438
Ie Ming Shih is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Ovarian cancer & Serous fluid. The author has an hindex of 97, co-authored 378 publications receiving 35329 citations. Previous affiliations of Ie Ming Shih include Howard Hughes Medical Institute & MedStar Washington Hospital Center.
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RSF1 Is a Positive Regulator of NF-κB–Induced Gene Expression Required for Ovarian Cancer Chemoresistance
TL;DR: It is demonstrated that RSF1 expression inversely correlated with paclitaxel response in patients with ovarian cancer and the mouse xenograft model, and coimmunoprecipitation data suggest that RSf1 may function as a coactivator for NF-κB, consequently augmenting expression of genes necessary for the development of chemoresistance in ovarian cancer cells.
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Diagnostic potential of tumor DNA from ovarian cyst fluid
Yuxuan Wang,Karin Sundfeldt,Constantina Mateoiu,Ie Ming Shih,Robert J. Kurman,Joy Schaefer,Natalie Silliman,Isaac Kinde,Simeon Springer,Michael B. Foote,Michael B. Foote,Björg Kristjansdottir,Nathan T. James,Kenneth W. Kinzler,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz,Bert Vogelstein +17 more
TL;DR: Though large, prospective studies are needed to demonstrate the safety and clinical utility of this approach, the results suggest that the genetic evaluation of cyst fluids might be able to inform the management of the large number of women with these lesions.
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Loss of ARID1A expression in endometrial samplings is associated with the risk of endometrial carcinoma.
Ting Tai Yen,Tsutomu Miyamoto,Tsutomu Miyamoto,Shiho Asaka,Shiho Asaka,M. Herman Chui,Yeh Wang,Shiou Fu Lin,Rebecca L. Stone,Amanda N. Fader,Ryoichi Asaka,Ryoichi Asaka,Hiroyasu Kashima,Tanri Shiozawa,Tian Li Wang,Ie Ming Shih,Edward J. Tanner +16 more
TL;DR: ARID1A immunostaining may correlate with malignant transformation and the presence of concurrent EEC in patients with CAH identified at pre-hysterectomy endometrial sampling.
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Chromosomal losses of regions on 5q and lack of high‐level amplifications at 8q24 are associated with favorable prognosis for ovarian serous carcinoma
Annette Staebler,Bianca Karberg,Juliane Behm,Petra Kuhlmann,Ulrike Neubert,Hartmut Schmidt,Eberhard Korsching,Horst Bürger,Ralph J. Lellé,Ludwig Kiesel,Werner Böcker,Ie Ming Shih,O. Buchweitz +12 more
TL;DR: In this paper, the authors describe characteristic chromosomal alterations in a consecutive series of 96 serous ovarian tumors by comparative genomic hybridization and analyze their association with different pathways of progression, histological grade, and clinical outcome.
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Telomere length in different histologic types of ovarian carcinoma with emphasis on clear cell carcinoma
Elisabetta Kuhn,Alan K. Meeker,Kala Visvanathan,Amy L. Gross,Tian Li Wang,Robert J. Kurman,Ie Ming Shih +6 more
TL;DR: Clear cell carcinomas have longer mean relative telomere lengths compared with the other histologic types and longer telomeres in clear cell carcinoma are associated with increased mortality suggesting that aberrations in telomer length may have an important role in the development and progression of this neoplasm.