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Ie Ming Shih
Researcher at Johns Hopkins University
Publications - 401
Citations - 40438
Ie Ming Shih is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Ovarian cancer & Serous fluid. The author has an hindex of 97, co-authored 378 publications receiving 35329 citations. Previous affiliations of Ie Ming Shih include Howard Hughes Medical Institute & MedStar Washington Hospital Center.
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The pathogenesis of atypical proliferative Brenner tumor: an immunohistochemical and molecular genetic analysis
TL;DR: The findings suggest that loss of CDKN2A and, to a lesser extent, KRAS and PIK3CA somatic mutations have a role in the progression of a benign to an atypical proliferative Brenner tumor.
Journal Article
Diagnostic and biological implications of Mel-CAM expression in mesenchymal neoplasms
TL;DR: Results show that Mel-CAM is expressed consistently in neoplasms of smooth muscle and vascular origin, and that immunostaining for Mel- CAM may serve as a useful adjunct in differentiating leiomyosarcoma, angiosarcomas, and Kaposi's sarcomas from other spindle cell neoplasm.
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Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference
Robert C. Bast,Ursula A. Matulonis,Anil K. Sood,Ahmed Ashour Ahmed,Adaobi E. Amobi,Frances R. Balkwill,Monicka Wielgos-Bonvallet,David D.L. Bowtell,James D. Brenton,Joan S. Brugge,Robert L. Coleman,Giulio Draetta,Kai Doberstein,Ronny Drapkin,Mark A. Eckert,Robert P. Edwards,Kevin M. Elias,Darren Ennis,Andrew Futreal,David M. Gershenson,Roger A. Greenberg,David G. Huntsman,Jennifer X Ji,Elise C. Kohn,Claudia Iavarone,Ernst Lengyel,Douglas A. Levine,Christopher J. Lord,Zhen Lu,Gordon B. Mills,Francesmary Modugno,Brad H. Nelson,Brad H. Nelson,Kunle Odunsi,Jessica A. Pilsworth,Robert Rottapel,Daniel J. Powell,Li Shen,Ie Ming Shih,David R. Spriggs,Josephine Walton,Kaiyang Zhang,Rugang Zhang,Lee Zou +43 more
TL;DR: The ability to accelerate progress in the clinic will depend on the ability to answer several critical questions regarding this disease, and an American Association for Cancer Research Special Conference on “Critical Questions in Ovarian Cancer Research and Treatment” was held in Pittsburgh, Pennsylvania, on October 1‐3, 2017.
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Characterization of the Immune Cell Repertoire in the Normal Fallopian Tube
Laura Ardighieri,Silvia Lonardi,Daniele Moratto,Fabio Facchetti,Ie Ming Shih,William Vermi,Robert J. Kurman +6 more
TL;DR: The cellular mapping that was performed indicates that the local immune system in the human fallopian tube is composed of a mixture of innate and adaptive immune cells, many of which are recognized as playing a role in cancer immune surveillance.
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RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis
Gong Yang,Gong Yang,Gong Yang,Imelda Mercado-Uribe,Asha S. Multani,Subrata Sen,Ie Ming Shih,Kwong Kwok Wong,David M. Gershenson,Jinsong Liu +9 more
TL;DR: In this paper, the authors measured the activity of the functionally related genes Aurora-A and BRCA2 in ovarian cancer cell lines and tumor samples containing RAS mutations, and they found that the imbalance in expression of Aurora -A and bRCA-2 regulates RAS-induced genomic instability and tumorigenesis.