Ikuo K. Suzuki

TL;DR: Long-read sequencing identifies a GGC repeat expansion in NOTCH2NLC that is associated with neuronal intranuclear inclusion disease, a progressive neurodegenerative disorder, and results in abnormal anti-sense transcripts that could contribute to disease pathogenesis.

TL;DR: This study uncovers a large repertoire of recently evolved genes active during human corticogenesis and reveals how human-specific NOTCH paralogs may have contributed to the expansion of the human cortex.

TL;DR: This Review examines stem cell-based approaches to analysing human brain development, from specification of particular cell types to building neuronal networks.

TL;DR: The authors report that the microcephaly results from induction of endoplasmic stress that interferes with generation and survival of projection neurons in the cerebral cortex, and administration of pharmacological inhibitors of unfolded protein response counteracts these pathophysiological mechanisms and prevents microCEphaly in ZIKV-infected mouse embryos.

TL;DR: The results suggest that the temporal sequence of the neocortical neurogenetic program was already inherent in the last common ancestor of mammals and birds and that mammals use this conserved program to generate a uniformly layered neocortex, whereas birds impose spatial constraints on the sequence to pattern the pallium.