K
Kevin Litchfield
Researcher at Francis Crick Institute
Publications - 77
Citations - 5075
Kevin Litchfield is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 25, co-authored 35 publications receiving 3208 citations. Previous affiliations of Kevin Litchfield include Queen Mary University of London & University College London.
Papers
More filters
Journal ArticleDOI
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis
Samra Turajlic,Samra Turajlic,Kevin Litchfield,Hang Xu,Rachel Rosenthal,Nicholas McGranahan,Nicholas McGranahan,James L. Reading,Yien Ning Sophia Wong,Andrew Rowan,Nnennaya Kanu,Maise Al Bakir,Tim Chambers,Roberto Salgado,Peter Savas,Sherene Loi,Nicolai Juul Birkbak,Laurent Sansregret,Martin Gore,James Larkin,Sergio A. Quezada,Charles Swanton,Charles Swanton +22 more
TL;DR: Evidence suggests indels are a highly immunogenic mutational class, which can trigger an increased abundance of neoantigens and greater mutant-binding specificity.
Journal ArticleDOI
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
Samra Turajlic,Samra Turajlic,Hang Xu,Kevin Litchfield,Andrew Rowan,Tim Chambers,José I. López,David Nicol,Tim O'Brien,James Larkin,Stuart Horswell,Mark Stares,Mark Stares,Lewis Au,Mariam Jamal-Hanjani,Ben Challacombe,Ashish Chandra,Steve Hazell,Claudia Eichler-Jonsson,Aspasia Soultati,Simon Chowdhury,Sarah Rudman,Joanna Lynch,Archana Fernando,Gordon Stamp,Emma Nye,Faiz Jabbar,Lavinia Spain,Sharanpreet Lall,Rosa Guarch,Mary Falzon,Ian Proctor,Lisa Pickering,Martin Gore,Thomas B.K. Watkins,Sophia Ward,Sophia Ward,Aengus Stewart,Renzo G. DiNatale,Maria F. Becerra,Ed Reznik,James J. Hsieh,Todd Richmond,George F. Mayhew,Samantha M. Hill,Catherine D. McNally,Carol Jones,Heidi Rosenbaum,Stacey Stanislaw,Daniel Burgess,Nelson Alexander,Charles Swanton,Charles Swanton +52 more
TL;DR: Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date, and 9p loss is identified as a highly selected event driving metastasis and ccRCC-related mortality.
Journal ArticleDOI
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
Samra Turajlic,Samra Turajlic,Hang Xu,Kevin Litchfield,Andrew Rowan,Stuart Horswell,Tim Chambers,Tim O'Brien,José I. López,Thomas B.K. Watkins,David Nicol,Mark Stares,Ben Challacombe,Steve Hazell,Ashish Chandra,Thomas J. Mitchell,Lewis Au,Claudia Eichler-Jonsson,Faiz Jabbar,Aspasia Soultati,Simon Chowdhury,Sarah Rudman,Joanna Lynch,Archana Fernando,Gordon Stamp,Emma Nye,Aengus Stewart,Wei Xing,Jonathan C. Smith,Mickael Escudero,Adam Huffman,Nik Matthews,Greg Elgar,Ben Phillimore,Marta Costa,Sharmin Begum,Sophia Ward,Sophia Ward,Max Salm,Stefan Boeing,Rosalie Fisher,Lavinia Spain,Carolina Navas,Eva Grönroos,Sebastijan Hobor,Sarkhara Sharma,Ismaeel Aurangzeb,Sharanpreet Lall,Alexander Polson,Mary Varia,Catherine Horsfield,Nicos Fotiadis,Lisa Pickering,Roland F. Schwarz,Bruno Silva,Javier Herrero,Nicholas M. Luscombe,Mariam Jamal-Hanjani,Rachel Rosenthal,Nicolai Juul Birkbak,Nicolai Juul Birkbak,Gareth A. Wilson,Gareth A. Wilson,Orsolya Pipek,Dezso Ribli,Marcin Krzystanek,István Csabai,Zoltan Szallasi,Zoltan Szallasi,Martin Gore,Nicholas McGranahan,Peter Van Loo,Peter Van Loo,Peter J. Campbell,James Larkin,Charles Swanton,Charles Swanton +76 more
TL;DR: The insights reconcile the variable clinical behavior of ccRCC and suggest evolutionary potential as a biomarker for both intervention and surveillance and identify genetic diversity and chromosomal complexity as determinants of patient outcome.
Journal ArticleDOI
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies
Frederick Arce Vargas,Andrew Furness,Kevin Litchfield,Kroopa Joshi,Rachel Rosenthal,Ehsan Ghorani,Isabelle Solomon,Marta H. Lesko,Nora Ruef,Claire Roddie,Jake Y. Henry,Lavinia Spain,Assma Ben Aissa,Andrew Georgiou,Yien Ning Sophia Wong,Myles Smith,Dirk C. Strauss,Andrew J. Hayes,David Nicol,Tim O'Brien,Linda Mårtensson,Anne Ljungars,Ingrid Teige,Björn Frendéus,TRACERx Melanoma,TRACERx Renal,TRACERx Lung consortia,Martin Pule,Teresa Marafioti,Martin Gore,James Larkin,Samra Turajlic,Charles Swanton,Karl S. Peggs,Sergio A. Quezada +34 more
TL;DR: The data suggest that the activity of anti-CTLA-4 in inflamed tumors may be improved through enhancement of FcγR binding, whereas poorly infiltrated tumors will likely require combination approaches.
Journal ArticleDOI
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
Philip C Haycock,Stephen Burgess,Aayah Nounu,Jie Zheng,G N Okoli,Jack Bowden,Kaitlin H Wade,Nicholas J. Timpson,David M. Evans,Peter Willeit,Abraham Aviv,Tom R. Gaunt,Gibran Hemani,Massimo Mangino,Hayley P Ellis,Kathreena M Kurian,Karen A. Pooley,Rosalind A. Eeles,Jeffrey E. Lee,Shenying Fang,Wei V. Chen,Matthew Law,Lisa Bowdler,Mark M. Iles,Qiong Yang,Bradford B. Worrall,Hugh S. Markus,Rayjean J. Hung,Christopher I. Amos,Amanda B. Spurdle,Deborah J. Thompson,Tracy A. O'Mara,Brian M. Wolpin,Laufey T. Amundadottir,Rachael Z. Stolzenberg-Solomon,Antonia Trichopoulou,N. Charlotte Onland-Moret,Eiliv Lund,Eric J. Duell,Federico Canzian,Gianluca Severi,Kim Overvad,Marc J. Gunter,Rosario Tumino,Ulrika Svenson,Andre M. van Rij,Annette F. Baas,Matthew J. Bown,Nilesh J. Samani,Femke N G van t'Hof,Gerard Tromp,Gregory T. Jones,Helena Kuivaniemi,James R. Elmore,Mattias Johansson,James McKay,Ghislaine Scelo,Robert Carreras-Torres,Valerie Gaborieau,Paul Brennan,Paige M. Bracci,Rachel E. Neale,Sara H. Olson,Steven Gallinger,Donghui Li,Gloria M. Petersen,Harvey A. Risch,Alison P. Klein,Jiali Han,Christian C. Abnet,Neal D. Freedman,Philip R. Taylor,John M. Maris,Katja K.H. Aben,Lambertus A. Kiemeney,Sita H. Vermeulen,John K. Wiencke,Kyle M. Walsh,Margaret Wrensch,Terri Rice,Clare Turnbull,Kevin Litchfield,Lavinia Paternoster,Marie Standl,Gonçalo R. Abecasis,John Paul SanGiovanni,Yong Li,Vladan Mijatovic,Yadav Sapkota,Siew-Kee Low,Krina T. Zondervan,Grant W. Montgomery,Dale R. Nyholt,David A. van Heel,Karen A. Hunt,Dan E. Arking,Foram N. Ashar,Nona Sotoodehnia,Daniel Woo,Jonathan Rosand,Mary E. Comeau,W. Mark Brown,Edwin K. Silverman,John E. Hokanson,Michael H. Cho,Jennie Hui,Manuel A. R. Ferreira,Philip J. Thompson,Alanna C. Morrison,Janine F. Felix,Nicholas L. Smith,Angela M. Christiano,Lynn Petukhova,Regina C. Betz,Xing Fan,Xuejun Zhang,Caihong Zhu,Carl D. Langefeld,Susan D. Thompson,Feijie Wang,Xu Lin,David A. Schwartz,Tasha E. Fingerlin,Jerome I. Rotter,Mary Frances Cotch,Richard A. Jensen,Matthias Munz,Henrik Dommisch,Arne S. Schaefer,Fang Han,Hanna Ollila,Ryan P. Hillary,Omar M. E. Albagha,Stuart H. Ralston,Chenjie Zeng,Wei Zheng,Xiao-Ou Shu,André Reis,Steffen Uebe,Ulrike Hüffmeier,Yoshiya Kawamura,Takeshi Otowa,Tsukasa Sasaki,Martin L. Hibberd,Sonia Davila,Gang Xie,Katherine A. Siminovitch,Jin-Xin Bei,Yi Xin Zeng,Asta Försti,Bowang Chen,Stefano Landi,Andre Franke,Annegret Fischer,David Ellinghaus,Carlos Flores,Imre Noth,Shwu-Fan Ma,Jia Nee Foo,Jianjun Liu,Jong-Won Kim,David G. Cox,Olivier Delattre,Olivier Mirabeau,Christine F. Skibola,Clara S. Tang,Merce Garcia-Barcelo,Kai-Ping Chang,Wen-Hui Su,Yu-Sun Chang,Nicholas G. Martin,Scott D. Gordon,Tracey D. Wade,Chaeyoung Lee,Michiaki Kubo,Pei-Chieng Cha,Yusuke Nakamura,Daniel Levy,Masayuki Kimura,Shih-Jen Hwang,Steven C. Hunt,Tim D. Spector,Nicole Soranzo,Ani Manichaikul,R. Graham Barr,Bratati Kahali,Elizabeth K. Speliotes,Laura M. Yerges-Armstrong,Ching-Yu Cheng,Jost B. Jonas,Tien Yin Wong,Isabella Fogh,Kuang Lin,John Powell,Kenneth Rice,Caroline L Relton,Richard M. Martin,George Davey Smith +197 more
TL;DR: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases, as well as single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population.