I
Irene M. Pedersen
Researcher at University of California, Irvine
Publications - 31
Citations - 4480
Irene M. Pedersen is an academic researcher from University of California, Irvine. The author has contributed to research in topics: microRNA & Apoptosis. The author has an hindex of 18, co-authored 31 publications receiving 4276 citations. Previous affiliations of Irene M. Pedersen include Discovery Institute & University of California, Berkeley.
Papers
More filters
Journal ArticleDOI
A unified model for apical caspase activation.
Kelly M. Boatright,Martin Renatus,Fiona L. Scott,Sabina Sperandio,Hwain Shin,Irene M. Pedersen,Jean-Ehrland Ricci,Wade Edris,Daniel P. Sutherlin,Douglas R. Green,Guy S. Salvesen +10 more
TL;DR: A unified caspase activation hypothesis is proposed whereby apical caspases are activated by dimerization of monomeric zymogens, and single amino acid substitutions at the dimer interface abrogate the activity of caspased-8 and -9 introduced into recipient mammalian cells.
Journal ArticleDOI
Interferon modulation of cellular microRNAs as an antiviral mechanism.
Irene M. Pedersen,Guofeng Cheng,Stefan Wieland,Stefano Volinia,Carlo M. Croce,Francis V. Chisari,Michael David +6 more
TL;DR: These findings strongly support the notion that mammalian organisms too, through the interferon system, use cellular miRNAs to combat viral infections.
Journal ArticleDOI
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Aaron D. Schimmer,Kate Welsh,Clemencia Pinilla,Zhiliang Wang,Maryla Krajewska,Marie-Josee Bonneau,Irene M. Pedersen,Shinichi Kitada,Fiona L. Scott,Béatrice Bailly-Maitre,Gennadi V. Glinsky,Dominick Scudiero,Edward A. Sausville,Guy S. Salvesen,Adel Nefzi,John M. Ostresh,Richard A. Houghten,John C. Reed +17 more
TL;DR: An enzyme derepression assay is developed, based on overcoming XIAP-mediated suppression of Caspase-3, and mixture-based combinatorial chemical libraries are screened for compounds that reversed XI AP-mediated inhibition of Cazase- 3, identifying a class of polyphenylureas with XIAP -inhibitory activity.
Journal ArticleDOI
Src homology 2 domain–containing inositol-5-phosphatase and CCAAT enhancer-binding protein β are targeted by miR-155 in B cells of Eμ-MiR-155 transgenic mice
Stefan Costinean,Sukhinder K. Sandhu,Irene M. Pedersen,Esmerina Tili,Rossana Trotta,Danilo Perrotti,David Ciarlariello,Paolo Neviani,Jason G. Harb,Lauren Rachel Kauffman,Aaditya Shidham,Carlo M. Croce +11 more
TL;DR: It is hypothesized that miR-155, by down-modulating Ship and C/EBPbeta, initiates a chain of events that leads to the accumulation of large pre-B cells and acute lymphoblastic leukemia/high-grade lymphoma.
Journal ArticleDOI
Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.
Irene M. Pedersen,Shinichi Kitada,Lorenzo M. Leoni,Juan M. Zapata,James G. Karras,Nobuhiro Tsukada,Thomas J. Kipps,Yong Sung Choi,Frank C. Bennett,John C. Reed +9 more
TL;DR: HK cells protect CLL B cells against apoptosis, at least in part through a CD44-dependent mechanism involving up-regulation of Mcl-1, and this mechanism is distinct from that achieved by CD40 ligation.