S
Simone Webb
Researcher at Newcastle University
Publications - 19
Citations - 1645
Simone Webb is an academic researcher from Newcastle University. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 8, co-authored 14 publications receiving 518 citations. Previous affiliations of Simone Webb include Ghent University.
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Journal ArticleDOI
Decoding human fetal liver haematopoiesis
Dorin-Mirel Popescu,Rachel A. Botting,Emily Stephenson,Kile Green,Simone Webb,Laura Jardine,Emily Calderbank,Krzysztof Polanski,Issac Goh,Mirjana Efremova,Meghan Acres,Daniel Maunder,Peter Vegh,Yorick Gitton,Jong-Eun Park,Roser Vento-Tormo,Zhichao Miao,Zhichao Miao,David Dixon,Rachel Rowell,David McDonald,James Fletcher,Elizabeth Poyner,Gary Reynolds,Michael W. Mather,Corina Moldovan,Lira Mamanova,Frankie Greig,Matthew D. Young,Kerstin B. Meyer,Steven Lisgo,Jaume Bacardit,Andrew Fuller,Ben Millar,Barbara A. Innes,Susan Lindsay,Michael J. T. Stubbington,Monika S. Kowalczyk,Bo Li,Orr Ashenberg,Marcin Tabaka,Danielle Dionne,Timothy L. Tickle,Timothy L. Tickle,Michal Slyper,Orit Rozenblatt-Rosen,Andrew Filby,Peter D. Carey,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Anindita Roy,Aviv Regev,Aviv Regev,Alain Chédotal,Irene Roberts,Berthold Göttgens,Sam Behjati,Sam Behjati,Elisa Laurenti,Sarah A. Teichmann,Sarah A. Teichmann,Muzlifah Haniffa,Muzlifah Haniffa +62 more
TL;DR: A shift in the haemopoietic composition of fetal liver during gestation away from being predominantly erythroid, accompanied by a parallel change in differentiation potential of HSC/MPPs is demonstrated, which is validated to produce an integrated map of fetal liver haematopoiesis.
Journal ArticleDOI
Single-cell multi-omics analysis of the immune response in COVID-19.
Emily Stephenson,Gary Reynolds,Rachel A. Botting,Fernando J Calero-Nieto,Michael D Morgan,Michael D Morgan,Zewen K. Tuong,Zewen K. Tuong,Karsten Bach,Karsten Bach,Waradon Sungnak,Kaylee B Worlock,Masahiro Yoshida,Natsuhiko Kumasaka,Katarzyna D. Kania,Justin Engelbert,Bayanne Olabi,Jarmila Stremenova Spegarova,Nicola K. Wilson,Nicole Mende,Laura Jardine,Louis C.S. Gardner,Issac Goh,Dave Horsfall,Jim McGrath,Simone Webb,Michael W. Mather,Rik G.H. Lindeboom,Emma Dann,Ni Huang,Krzysztof Polanski,Elena Prigmore,Florian Gothe,Florian Gothe,Jonathan M. Scott,Rebecca Payne,Kenneth F Baker,Kenneth F Baker,Aidan T Hanrath,Aidan T Hanrath,Ina Schim van der Loeff,Andrew Barr,Amada Sanchez-Gonzalez,Laura Bergamaschi,Federica Mescia,Josephine Barnes,Eliz Kilich,Angus de Wilton,A Saigal,Aarash Saleh,Sam M. Janes,Sam M. Janes,Claire Smith,Nusayhah Gopee,Caroline Wilson,Caroline Wilson,Paul Coupland,Jonathan Coxhead +57 more
TL;DR: In this article, the authors performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19.
Journal ArticleDOI
A cell atlas of human thymic development defines T cell repertoire formation.
Jong-Eun Park,Rachel A. Botting,Cecilia Domínguez Conde,Dorin-Mirel Popescu,Marieke Lavaert,Daniel J Kunz,Daniel J Kunz,Daniel J Kunz,Issac Goh,Emily Stephenson,Roberta Ragazzini,Roberta Ragazzini,Elizabeth Tuck,Anna Wilbrey-Clark,Kenny Roberts,Veronika R. Kedlian,John R. Ferdinand,Xiaoling He,Simone Webb,Daniel Maunder,Niels Vandamme,Krishnaa T. Mahbubani,Krzysztof Polanski,Lira Mamanova,Liam Bolt,David Crossland,David Crossland,Fabrizio De Rita,Andrew Fuller,Andrew Filby,Gary Reynolds,David Dixon,Kourosh Saeb-Parsy,Steven Lisgo,Deborah J. Henderson,Roser Vento-Tormo,Omer Ali Bayraktar,Roger A. Barker,Kerstin B. Meyer,Yvan Saeys,Paola Bonfanti,Paola Bonfanti,Sam Behjati,Sam Behjati,Menna R. Clatworthy,Menna R. Clatworthy,Menna R. Clatworthy,Tom Taghon,Muzlifah Haniffa,Muzlifah Haniffa,Sarah A. Teichmann,Sarah A. Teichmann +51 more
TL;DR: The authors' single-cell transcriptome profile of the thymus across the human lifetime and across species provides a high-resolution census of T cell development within the native tissue microenvironment, and identifies novel subpopulations of human thymic fibroblasts and epithelial cells and located them in situ.
Journal ArticleDOI
Developmental cell programs are co-opted in inflammatory skin disease
Gary Reynolds,Peter Vegh,James Fletcher,Elizabeth Poyner,Emily Stephenson,Issac Goh,Rachel A. Botting,Ni Huang,Bayanne Olabi,Bayanne Olabi,Anna Dubois,David Dixon,Kile Green,Daniel Maunder,Justin Engelbert,Mirjana Efremova,Krzysztof Polanski,Laura Jardine,C Jones,Thomas Ness,Dave Horsfall,Jim McGrath,Christopher D. Carey,Dorin-Mirel Popescu,Simone Webb,Xiao-Nong Wang,Ben Sayer,Jong-Eun Park,Victor A. Negri,Daria Belokhvostova,Magnus D. Lynch,David McDonald,Andrew Filby,Tzachi Hagai,Kerstin B. Meyer,A. Husain,Jonathan Coxhead,Roser Vento-Tormo,Sam Behjati,Sam Behjati,Steven Lisgo,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Jaume Bacardit,Philip H. Jones,Philip H. Jones,Edel A. O'Toole,Graham S. Ogg,Neil Rajan,Nick J. Reynolds,Sarah A. Teichmann,Sarah A. Teichmann,Fiona M. Watt,Muzlifah Haniffa,Muzlifah Haniffa +54 more
TL;DR: In this paper, the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and psoriasis were compared across development, homeostasis, and disease.
Posted ContentDOI
A cell atlas of human thymic development defines T cell repertoire formation
Jong-Eun Park,Rachel A. Botting,Cecilia Domínguez Conde,Dorin-Mirel Popescu,Marieke Lavaert,Daniel J Kunz,Daniel J Kunz,Daniel J Kunz,Emily Stephenson,Roberta Ragazzini,Elizabeth Tuck,Anna Wilbrey-Clark,John R. Ferdinand,Simone Webb,Daniel Maunder,Niels Vandamme,Krishnaa T. Mahbubani,Krzysztof Polanski,Lira Mamanova,Andrew Fuller,Andrew Filby,Gary Reynolds,David Dixon,Kourosh Saeb-Parsy,Steven Lisgo,Deborah J. Henderson,Roser Vento-Tormo,Kerstin B. Meyer,Yvan Saeys,Paola Bonfanti,Paola Bonfanti,Sam Behjati,Menna R. Clatworthy,Menna R. Clatworthy,Tom Taghon,Muzlifah Haniffa,Muzlifah Haniffa,Sarah A. Teichmann,Sarah A. Teichmann +38 more
TL;DR: A bias in TCR recombination and selection is revealed, which is attributed to genomic position and suggests later commitment of the CD8+ T-cell lineage, and a comprehensive atlas of the human thymus across the lifespan is provided.