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Irina Astrovskaya
Publications - 4
Citations - 423
Irina Astrovskaya is an academic researcher. The author has contributed to research in topics: Autism & Autism spectrum disorder. The author has an hindex of 3, co-authored 4 publications receiving 241 citations.
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Journal ArticleDOI
SPARK: A US Cohort of 50,000 Families to Accelerate Autism Research
Pamela Feliciano,Amy M. Daniels,LeeAnne Green Snyder,Amy L. Beaumont,Alexies Camba,Amy Esler,Amanda G. Gulsrud,Andrew Mason,Anibal Gutierrez,Amy Nicholson,Anna Marie Paolicelli,Alexander P. McKenzie,Angela L. Rachubinski,Alexandra N. Stephens,Andrea R Simon,Amy Stedman,Amanda D. Shocklee,Amy Swanson,Brenda Finucane,Brittani A. Hilscher,Brenda Hauf,Brian J. O'Roak,Brooke G. McKenna,Beverly E. Robertson,Barbara Rodriguez,Brianna M. Vernoia,Bonnie Van Metre,Catherine C. Bradley,Cheryl Cohen,Craig A. Erickson,Christina Harkins,Caitlin Hayes,Catherine Lord,Christa Lese Martin,Crissy Ortiz,Cesar Ochoa-Lubinoff,Christine Peura,Catherine Rice,Cordelia Robinson Rosenberg,Christopher J. Smith,Carrie Thomas,Cora Taylor,Loran Casey White,Corrie H. Walston,David G. Amaral,Daniel L. Coury,Dustin E. Sarver,Dalia Istephanous,Deana Li,Dzung Cong Nugyen,Emily A. Fox,Eric Butter,Elizabeth Berry-Kravis,Eric Courchesne,Eric Fombonne,Eugenia Hofammann,Elena Lamarche,Ericka L. Wodka,Emily T. Matthews,Eirene O’Connor,Emily Palen,Fiona Miller,Gabriel S. Dichter,Gabriela Marzano,Gail Stein,Hanna Hutter,Hannah E. Kaplan,Hai Li,Holly Lechniak,Hoa Lam Schneider,Hana Zaydens,Ivette Arriaga,Jennifer A. Gerdts,Joseph F. Cubells,Jeanette M. Cordova,Jaclyn Gunderson,Joseph Lillard,Julie Manoharan,James T. McCracken,Jacob J. Michaelson,Jason Neely,Jessica Orobio,Juhi Pandey,Joseph Piven,Jessica Scherr,James S. Sutcliffe,Jennifer Tjernagel,Jermel Wallace,Kristen Callahan,Katherine Dent,Kathryn A. Schweers,Kira E. Hamer,J. Kiely Law,Kathryn Lowe,Kaela O’Brien,Kaitlin Smith,Katherine G. Pawlowski,Karen Pierce,Katherine Roeder,Leonard J Abbeduto,Leandra N. Berry,Lindsey A. Cartner,Leigh A. Coppola,Laura A. Carpenter,Lisa Cordeiro,Lindsey DeMarco,Luke P. Grosvenor,Lorrin Higgins,Lark Huang-Storms,Landon Hosmer-Quint,Lynette M. Herbert,Lauren Kasparson,Lisa M. Prock,Lillian D. Pacheco,Laurie Raymond,Laura Simon,Latha Soorya,Lucy Wasserburg,Maya Lazar,Michael Alessandri,Melissa Brown,Mary Hannah Currin,McLeod F. Gwynette,Michelle Heyman,Melissa N. Hale,Mark Jones,Michelle Jordy,Michael J. Morrier,Mustafa Sahin,Matthew S. Siegel,Mary Verdi,Meaghan V. Parladé,Meredith Yinger,Nicole Bardett,Nathan Hanna,Nina Harris,Natalie Pottschmidt,Nicole M. Russo-Ponsaran,Nicole Takahashi,Opal Y. Ousley,A. Pablo Juárez,Patricia Manning,Robert D. Annett,Raphael Bernier,Renee D. Clark,Rebecca Landa,Robin P. Goin-Kochel,Rick Remington,Robert T. Schultz,Stephanie J. Brewster,Stephanie Booker,Sarah Carpenter,Sara Eldred,Sunday M. Francis,Sandra L. Friedman,Susannah Horner,Susan Hepburn,Suma Jacob,Stephen M. Kanne,Soo J. Lee,Sarah Mastel,Samantha Plate,Shanping Qiu,Sophia Sandhu,Samantha Thompson,Sabrina White,Vincent Myers,Vini Singh,Wha S. Yang,Zachary Warren,Alpha Amatya,Andrea J. Ace,Ahmad S. Chatha,Alex E. Lash,Ben Negron,Chris Rigby,Curtis Ridenour,Colleen M. Stock,Danielle Schmidt,Ian Fisk,John Acampado,Jay L. Nestle,Jay A. Nestle,Kevin Layman,Martin Butler,Matt Kent,Malcolm D. Mallardi,Nicholas Carriero,Noah Lawson,Natalia Volfovsky,Ron Edgar,Richard Marini,Rishiraj Rana,Swami Ganesan,Swapnil Shah,Tyler Ramsey,Wubin Chin,William Jensen,Anthony D. Krentz,Angela J. Gruber,Aniko Sabo,Andrei Salomatov,Christine M. Eng,Donna M. Muzny,Irina Astrovskaya,Richard A. Gibbs,Xinwei Han,Yufeng Shen,Louis F. Reichardt,Wendy K. Chung +209 more
TL;DR: The Simons Foundation Autism Research Initiative (SFARI) has launched SPARKForAutism.org, a dynamic platform that is engaging thousands of individuals with autism spectrum disorder (ASD) and connecting them to researchers.
Journal ArticleDOI
Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes.
Pamela Feliciano,Xueya Zhou,Irina Astrovskaya,Tychele N. Turner,Tianyun Wang,Leo Brueggeman,Rebecca A. Barnard,Alexander Hsieh,LeeAnne Green Snyder,Donna M. Muzny,Aniko Sabo,Richard A. Gibbs,Evan E. Eichler,Brian J. O'Roak,Jacob J. Michaelson,Natalia Volfovsky,Yufeng Shen,Wendy K. Chung +17 more
TL;DR: A pilot study for SPARK identified variants in genes and loci that are clinically recognized causes or significant contributors to ASD in 10.4% of families without previous genetic findings, and BRSK2 has the strongest statistical support and reaches genome-wide significance as a risk gene for ASD.
Journal ArticleDOI
Exome sequencing of 457 autism families recruited online provides evidence for novel ASD genes
Pamela Feliciano,Xueya Zhou,Irina Astrovskaya,Tychele N. Turner,Tianyun Wang,Leo Brueggeman,Rebecca A. Barnard,Alexander Hsieh,LeeAnne Green Snyder,Donna M. Muzny,Aniko Sabo,Richard A. Gibbs,Evan E. Eichler,Brian J. O'Roak,Jacob J. Michaelson,Natalia Volfovsky,Yufeng Shen,Wendy K. Chung +17 more
TL;DR: A pilot study for SPARK identified variants in genes and loci that are clinically recognized causes or significant contributors to ASD in 10.4% of families without previous genetic findings and provides statistical support for 34 ASD risk genes with at least one damaging variant identified in SPARK.
Posted ContentDOI
Integrating de novo and inherited variants in over 42,607 autism cases identifies mutations in new moderate risk genes
Xueya Zhou,Pamela Feliciano,Tianyun Wang,Irina Astrovskaya,Chang Shu,Jacob B. Hall,Joseph U. Obiajulu,Jessica Wright,Shwetha C. Murali,Simon Xuming Xu,Leo Brueggeman,Taylor R. Thomas,Olena Marchenko,Christopher Fleisch,Sarah D. Barns,LeeAnne Green Snyder,Bing Han,Timothy S. Chang,Tychele N. Turner,William T. Harvey,Andrew Nishida,Brian J. O'Roak,Daniel H. Geschwind,Jacob J. Michaelson,Natalia Volfovsky,Evan E. Eichler,Yufeng Shen,Wendy K. Chung +27 more
TL;DR: This article performed a two-stage analysis of rare de novo and inherited coding variants in 42,607 ASD cases, including 35,130 new cases recruited online by SPARK, and identified 60 genes with exome-wide significance.