T
Tychele N. Turner
Researcher at Washington University in St. Louis
Publications - 64
Citations - 3473
Tychele N. Turner is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Autism & Gene. The author has an hindex of 23, co-authored 53 publications receiving 2445 citations. Previous affiliations of Tychele N. Turner include Johns Hopkins University & Broad Institute.
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Journal ArticleDOI
Excess of rare, inherited truncating mutations in autism.
Niklas Krumm,Tychele N. Turner,Carl Baker,Laura Vives,Kiana Mohajeri,Kali Witherspoon,Archana Raja,Bradley P. Coe,Holly A.F. Stessman,Zong Xiao He,Suzanne M. Leal,Raphael Bernier,Evan E. Eichler +12 more
TL;DR: This analysis identifies a second class of candidate genes (for example, RIMS1, CUL7 and LZTR1) where transmitted mutations may create a sensitized background but are unlikely to be completely penetrant, and private truncating SNVs and rare, inherited CNVs are statistically independent risk factors for autism.
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Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases
Holly A.F. Stessman,Bo Xiong,Bo Xiong,Bradley P. Coe,Tianyun Wang,Kendra Hoekzema,Kendra Hoekzema,Michaela Fenckova,Malin Kvarnung,Jennifer Gerdts,Sandy Trinh,Nele Cosemans,Laura Vives,Janice Lin,Tychele N. Turner,Gijs W. E. Santen,Claudia A. L. Ruivenkamp,Marjolein Kriek,Arie van Haeringen,Emmelien Aten,Kathryn Friend,Kathryn Friend,Jan Liebelt,Christopher Barnett,Eric Haan,Eric Haan,Marie Shaw,Jozef Gecz,Jozef Gecz,Jozef Gecz,Britt-Marie Anderlid,Ann Nordgren,Anna Lindstrand,Charles E. Schwartz,R. Frank Kooy,Geert Vandeweyer,Céline Helsmoortel,Corrado Romano,Antonino Alberti,Mirella Vinci,Emanuela Avola,Stefania Giusto,Eric Courchesne,Tiziano Pramparo,Karen Pierce,Srinivasa Nalabolu,David G. Amaral,Ingrid E. Scheffer,Ingrid E. Scheffer,Martin B. Delatycki,Paul J. Lockhart,Fereydoun Hormozdiari,Benjamin Harich,Anna Castells-Nobau,Kun Xia,Hilde Peeters,Magnus Nordenskjöld,Annette Schenck,Raphael Bernier,Evan E. Eichler,Evan E. Eichler +60 more
TL;DR: Twenty-five genes showing a bias for autism versus intellectual disability and a network associated with high-functioning autism are highlighted, and clinical follow-up for NAA15, KMT5B, and ASH1L highlighted new syndromic and nonsyndromic forms of disease.
Journal ArticleDOI
Genomic Patterns of De Novo Mutation in Simplex Autism
Tychele N. Turner,Bradley P. Coe,Diane E. Dickel,Kendra Hoekzema,Bradley J. Nelson,Michael C. Zody,Zev N. Kronenberg,Fereydoun Hormozdiari,Archana Raja,Len A. Pennacchio,Robert B. Darnell,Evan E. Eichler +11 more
TL;DR: Patients are more likely to carry multiple coding and noncoding DNMs in different genes, which are enriched for expression in striatal neurons, suggesting a path forward for genetically characterizing more complex cases of autism.
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De novo genic mutations among a Chinese autism spectrum disorder cohort
Tianyun Wang,Hui Guo,Bo Xiong,Holly A.F. Stessman,Huidan Wu,Bradley P. Coe,Tychele N. Turner,Yanling Liu,Wenjing Zhao,Kendra Hoekzema,Laura Vives,Lu Xia,Meina Tang,Jianjun Ou,Biyuan Chen,Yidong Shen,Guanglei Xun,Min Long,Janice Lin,Zev N. Kronenberg,Yu Peng,Ting Bai,Honghui Li,Xiaoyan Ke,Zhengmao Hu,Jingping Zhao,Xiaobing Zou,Kun Xia,Evan E. Eichler +28 more
TL;DR: Phenotypic follow-up confirms potential subtypes and highlights how large global cohorts might be leveraged to prove the pathogenic significance of individually rare mutations.
Journal ArticleDOI
Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative Noncoding Regulatory DNA
Tychele N. Turner,Fereydoun Hormozdiari,Michael H. Duyzend,Sarah A. McClymont,Paul W. Hook,Ivan Iossifov,Archana Raja,Carl Baker,Kendra Hoekzema,Holly A.F. Stessman,Michael C. Zody,Bradley J. Nelson,John Huddleston,Richard Sandstrom,Joshua D. Smith,David S. Hanna,James M. Swanson,Elaine M. Faustman,Michael J. Bamshad,John A. Stamatoyannopoulos,Deborah A. Nickerson,Andrew S. McCallion,Robert B. Darnell,Robert B. Darnell,Evan E. Eichler +24 more
TL;DR: The results suggest that the detection of smaller, often multiple CNVs affecting putative regulatory elements might help explain additional risk of simplex autism.