T
Tianyun Wang
Researcher at University of Washington
Publications - 39
Citations - 2115
Tianyun Wang is an academic researcher from University of Washington. The author has contributed to research in topics: Autism & Autism spectrum disorder. The author has an hindex of 15, co-authored 29 publications receiving 1305 citations. Previous affiliations of Tianyun Wang include Central South University.
Papers
More filters
Journal ArticleDOI
Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases
Holly A.F. Stessman,Bo Xiong,Bo Xiong,Bradley P. Coe,Tianyun Wang,Kendra Hoekzema,Kendra Hoekzema,Michaela Fenckova,Malin Kvarnung,Jennifer Gerdts,Sandy Trinh,Nele Cosemans,Laura Vives,Janice Lin,Tychele N. Turner,Gijs W. E. Santen,Claudia A. L. Ruivenkamp,Marjolein Kriek,Arie van Haeringen,Emmelien Aten,Kathryn Friend,Kathryn Friend,Jan Liebelt,Christopher Barnett,Eric Haan,Eric Haan,Marie Shaw,Jozef Gecz,Jozef Gecz,Jozef Gecz,Britt-Marie Anderlid,Ann Nordgren,Anna Lindstrand,Charles E. Schwartz,R. Frank Kooy,Geert Vandeweyer,Céline Helsmoortel,Corrado Romano,Antonino Alberti,Mirella Vinci,Emanuela Avola,Stefania Giusto,Eric Courchesne,Tiziano Pramparo,Karen Pierce,Srinivasa Nalabolu,David G. Amaral,Ingrid E. Scheffer,Ingrid E. Scheffer,Martin B. Delatycki,Paul J. Lockhart,Fereydoun Hormozdiari,Benjamin Harich,Anna Castells-Nobau,Kun Xia,Hilde Peeters,Magnus Nordenskjöld,Annette Schenck,Raphael Bernier,Evan E. Eichler,Evan E. Eichler +60 more
TL;DR: Twenty-five genes showing a bias for autism versus intellectual disability and a network associated with high-functioning autism are highlighted, and clinical follow-up for NAA15, KMT5B, and ASH1L highlighted new syndromic and nonsyndromic forms of disease.
Journal ArticleDOI
De novo genic mutations among a Chinese autism spectrum disorder cohort
Tianyun Wang,Hui Guo,Bo Xiong,Holly A.F. Stessman,Huidan Wu,Bradley P. Coe,Tychele N. Turner,Yanling Liu,Wenjing Zhao,Kendra Hoekzema,Laura Vives,Lu Xia,Meina Tang,Jianjun Ou,Biyuan Chen,Yidong Shen,Guanglei Xun,Min Long,Janice Lin,Zev N. Kronenberg,Yu Peng,Ting Bai,Honghui Li,Xiaoyan Ke,Zhengmao Hu,Jingping Zhao,Xiaobing Zou,Kun Xia,Evan E. Eichler +28 more
TL;DR: Phenotypic follow-up confirms potential subtypes and highlights how large global cohorts might be leveraged to prove the pathogenic significance of individually rare mutations.
Journal ArticleDOI
Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes.
Pamela Feliciano,Xueya Zhou,Irina Astrovskaya,Tychele N. Turner,Tianyun Wang,Leo Brueggeman,Rebecca A. Barnard,Alexander Hsieh,LeeAnne Green Snyder,Donna M. Muzny,Aniko Sabo,Richard A. Gibbs,Evan E. Eichler,Brian J. O'Roak,Jacob J. Michaelson,Natalia Volfovsky,Yufeng Shen,Wendy K. Chung +17 more
TL;DR: A pilot study for SPARK identified variants in genes and loci that are clinically recognized causes or significant contributors to ASD in 10.4% of families without previous genetic findings, and BRSK2 has the strongest statistical support and reaches genome-wide significance as a risk gene for ASD.
Journal ArticleDOI
Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains.
Madeleine R. Geisheker,Gabriel Heymann,Tianyun Wang,Bradley P. Coe,Tychele N. Turner,Holly A.F. Stessman,Kendra Hoekzema,Malin Kvarnung,Marie Shaw,Kathryn Friend,Kathryn Friend,Jan Liebelt,Christopher Barnett,Christopher Barnett,Elizabeth Thompson,Elizabeth Thompson,Eric Haan,Eric Haan,Hui Guo,Britt-Marie Anderlid,Ann Nordgren,Anna Lindstrand,Geert Vandeweyer,Antonino Alberti,Emanuela Avola,Mirella Vinci,Stefania Giusto,Tiziano Pramparo,Karen Pierce,Srinivasa Nalabolu,Jacob J. Michaelson,Zdenek Sedlacek,Gijs W. E. Santen,Hilde Peeters,Hakon Hakonarson,Eric Courchesne,Corrado Romano,R. Frank Kooy,Raphael Bernier,Magnus Nordenskjöld,Jozef Gecz,Kun Xia,Larry S. Zweifel,Evan E. Eichler,Evan E. Eichler +44 more
TL;DR: Overall, significant clustering of de novo mutations in 200 genes is found, highlighting specific functional domains and synaptic candidate genes important in NDD pathology.
Journal ArticleDOI
Disruption of POGZ Is Associated with Intellectual Disability and Autism Spectrum Disorders
Holly A.F. Stessman,Marjolein H. Willemsen,Michaela Fenckova,Osnat Penn,Alexander Hoischen,Bo Xiong,Tianyun Wang,Kendra Hoekzema,Laura Vives,Ida Vogel,Han G. Brunner,Han G. Brunner,Ineke van der Burgt,Charlotte W. Ockeloen,Janneke H M Schuurs-Hoeijmakers,Jolien S. Klein Wassink-Ruiter,Connie T.R.M. Stumpel,Servi J. C. Stevens,Hans S.H. Vles,Carlo M. Marcelis,Hans van Bokhoven,Vincent Cantagrel,Vincent Cantagrel,Laurence Colleaux,Laurence Colleaux,Michael Nicouleau,Michael Nicouleau,Stanislas Lyonnet,Stanislas Lyonnet,Stanislas Lyonnet,Raphael Bernier,Jennifer Gerdts,Bradley P. Coe,Corrado Romano,Antonino Alberti,Lucia Grillo,Carmela Scuderi,Magnus Nordenskjöld,Malin Kvarnung,Hui Guo,Kun Xia,Amélie Piton,Bénédicte Gérard,David Geneviève,Bruno Delobel,Daphné Lehalle,Laurence Perrin,Fabienne Prieur,Julien Thevenon,Jozef Gecz,Marie Shaw,Rolph Pfundt,Boris Keren,Aurélia Jacquette,Annette Schenck,Evan E. Eichler,Evan E. Eichler,Tjitske Kleefstra +57 more
TL;DR: Common phenotypic features of POGZ individuals, including variable levels of developmental delay (DD) and more severe speech and language delay in comparison to the severity of motor delay and coordination issues, are defined.