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Irina Kufareva
Researcher at University of Montana
Publications - 112
Citations - 7670
Irina Kufareva is an academic researcher from University of Montana. The author has contributed to research in topics: Chemokine receptor & G protein-coupled receptor. The author has an hindex of 38, co-authored 106 publications receiving 6417 citations. Previous affiliations of Irina Kufareva include Tomsk State University & University of California, San Diego.
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Journal ArticleDOI
Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease
Tiago F. Outeiro,Eirene Kontopoulos,Stephen M. Altmann,Irina Kufareva,Katherine E. Strathearn,Allison M. Amore,Catherine B. Volk,Michele M. Maxwell,Jean-Christophe Rochet,Pamela J. McLean,Anne B. Young,Ruben Abagyan,Mel B. Feany,Bradley T. Hyman,Aleksey G. Kazantsev +14 more
TL;DR: A potent inhibitor of sIRT2 was identified and inhibition of SIRT2 rescued α-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease, suggesting a link between neurodegeneration and aging.
Journal ArticleDOI
Structure of the CCR5 Chemokine Receptor–HIV Entry Inhibitor Maraviroc Complex
Qiuxiang Tan,Ya Zhu,Jian Li,Z.H. Chen,Gye Won Han,Irina Kufareva,Tingting Li,Limin Ma,Gustavo Fenalti,Jing Li,Wenru Zhang,Xin Xie,Huaiyu Yang,Hualiang Jiang,Vadim Cherezov,Hong Liu,Raymond C. Stevens,Raymond C. Stevens,Raymond C. Stevens,Qiang Zhao,Beili Wu +20 more
TL;DR: The 2.7 angstrom–resolution crystal structure of human CCR5 bound to the marketed HIV drug maraviroc reveals a ligand-binding site that is distinct from the proposed major recognition sites for chemokines and the viral glycoprotein gp120, providing insights into the mechanism of allosteric inhibition of chemokine signaling and viral entry.
Journal ArticleDOI
Crystal Structure of the Human Cannabinoid Receptor CB2.
Tian Hua,Kiran Vemuri,Mengchen Pu,Lu Qu,Lu Qu,Gye Won Han,Yiran Wu,Suwen Zhao,Wenqing Shui,Shanshan Li,Anisha Korde,Robert B. Laprairie,Edward L. Stahl,Jo-Hao Ho,Nikolai Zvonok,Han Zhou,Irina Kufareva,Beili Wu,Qiang Zhao,Michael A. Hanson,Laura M. Bohn,Alexandros Makriyannis,Raymond C. Stevens,Raymond C. Stevens,Zhi-Jie Liu,Zhi-Jie Liu +25 more
TL;DR: The structure of the CB1-AM6538 complex reveals key features of the receptor and critical interactions for antagonist binding and provides insight into the binding mode of naturally occurring CB1 ligands, such as THC, and synthetic cannabinoids.
Journal ArticleDOI
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
Morgan O'Hayre,José Vázquez-Prado,Irina Kufareva,Eric Stawiski,Tracy M. Handel,Somasekar Seshagiri,J. Silvio Gutkind +6 more
TL;DR: Deep sequencing studies indicate that G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment.
Book ChapterDOI
Methods of Protein Structure Comparison
Irina Kufareva,Ruben Abagyan +1 more
TL;DR: Several methods routinely used to compare computational models to experimental answers in several modeling assessments are described and the importance of using combined measures, utility-based measures, and the role of the distributions derived from the pairs of experimental structures in interpreting the results are illustrated.