M
Mengchen Pu
Researcher at ShanghaiTech University
Publications - 11
Citations - 1252
Mengchen Pu is an academic researcher from ShanghaiTech University. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 7, co-authored 7 publications receiving 941 citations. Previous affiliations of Mengchen Pu include Chinese Academy of Sciences.
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Journal ArticleDOI
Crystal Structure of the Human Cannabinoid Receptor CB2.
Tian Hua,Kiran Vemuri,Mengchen Pu,Lu Qu,Lu Qu,Gye Won Han,Yiran Wu,Suwen Zhao,Wenqing Shui,Shanshan Li,Anisha Korde,Robert B. Laprairie,Edward L. Stahl,Jo-Hao Ho,Nikolai Zvonok,Han Zhou,Irina Kufareva,Beili Wu,Qiang Zhao,Michael A. Hanson,Laura M. Bohn,Alexandros Makriyannis,Raymond C. Stevens,Raymond C. Stevens,Zhi-Jie Liu,Zhi-Jie Liu +25 more
TL;DR: The structure of the CB1-AM6538 complex reveals key features of the receptor and critical interactions for antagonist binding and provides insight into the binding mode of naturally occurring CB1 ligands, such as THC, and synthetic cannabinoids.
Journal ArticleDOI
Crystal structures of agonist-bound human cannabinoid receptor CB1
Tian Hua,Kiran Vemuri,Spyros P. Nikas,Robert B. Laprairie,Yiran Wu,Lu Qu,Lu Qu,Mengchen Pu,Anisha Korde,Shan Jiang,Jo-Hao Ho,Gye Won Han,Kang Ding,Kang Ding,Xuanxuan Li,Haiguang Liu,Michael A. Hanson,Suwen Zhao,Laura M. Bohn,Alexandros Makriyannis,Raymond C. Stevens,Raymond C. Stevens,Zhi-Jie Liu,Zhi-Jie Liu +23 more
TL;DR: The structures reveal important insights into the activation mechanism of CB1 and provide a molecular basis for predicting the binding modes of Δ9-THC, and endogenous and synthetic cannabinoids and should inspire the design of chemically diverse ligands with distinct pharmacological properties.
Journal ArticleDOI
5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Yao Peng,Yao Peng,Yao Peng,John D. McCorvy,Kasper Harpsøe,Katherine Lansu,Shuguang Yuan,Petr Popov,Petr Popov,Lu Qu,Lu Qu,Mengchen Pu,Tao Che,Louise F. Nikolajsen,Louise F. Nikolajsen,Xi Ping Huang,Yiran Wu,Ling Shen,Walden E. Bjørn-Yoshimoto,Kang Ding,Daniel Wacker,Gye Won Han,Jianjun Cheng,Vsevolod Katritch,Vsevolod Katritch,Anders A. Jensen,Michael A. Hanson,Suwen Zhao,David E. Gloriam,Bryan L. Roth,Raymond C. Stevens,Raymond C. Stevens,Zhi-Jie Liu +32 more
TL;DR: This study investigates the structural basis of polypharmacology at canonical GPCRs and illustrates how understanding characteristic patterns of ligand-receptor interaction and activation may ultimately facilitate drug design at multiple GPCR.
Journal ArticleDOI
Native phasing of x-ray free-electron laser data for a G protein-coupled receptor.
Alexander Batyuk,Lorenzo Galli,Andrii Ishchenko,Gye Won Han,Cornelius Gati,Petr Popov,Petr Popov,Ming-Yue Lee,Benjamin Stauch,Thomas A. White,Anton Barty,Andrew Aquila,Mark S. Hunter,Mengning Liang,Sébastien Boutet,Mengchen Pu,Zhi-Jie Liu,Zhi-Jie Liu,Garrett Nelson,Daniel James,Chufeng Li,Yun Zhao,John C. H. Spence,Wei Liu,Petra Fromme,Vsevolod Katritch,Uwe Weierstall,Raymond C. Stevens,Vadim Cherezov +28 more
TL;DR: The ability to solve the crystallographic phase problem for SFX data collected with an XFEL using the anomalous signal from native sulfur atoms is demonstrated, leading to a bias-free room temperature structure of the human A2A adenosine receptor at 1.9 Å resolution.
Journal ArticleDOI
Crystal structure of the Frizzled 4 receptor in a ligand-free state
Shifan Yang,Yiran Wu,Ting-Hai Xu,Parker W. de Waal,Yuanzheng He,Mengchen Pu,Yuxiang Chen,Zachary J. DeBruine,Bingjie Zhang,Saheem A. Zaidi,Petr Popov,Petr Popov,Yu Guo,Gye Won Han,Lu Yang,Kelly Suino-Powell,Shaowei Dong,Kaleeckal G. Harikumar,Laurence J. Miller,Vsevolod Katritch,Vsevolod Katritch,H. Eric Xu,H. Eric Xu,Wenqing Shui,Raymond C. Stevens,Karsten Melcher,Suwen Zhao,Fei Xu +27 more
TL;DR: The stability of the structure in its ligand-free form, an unfavourable pocket for ligand binding and the two unusual kinks on helix VII suggest that FZDs may have evolved a novelligand-recognition and activation mechanism that is distinct from that of other GPCRs.