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Bagrat Abazyan
Researcher at Johns Hopkins University School of Medicine
Publications - 13
Citations - 1100
Bagrat Abazyan is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: DISC1 & Astrocyte. The author has an hindex of 12, co-authored 13 publications receiving 997 citations. Previous affiliations of Bagrat Abazyan include Johns Hopkins University & University of Maryland, Baltimore.
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Journal ArticleDOI
Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology.
Bagrat Abazyan,Jun Nomura,Geetha Kannan,Koko Ishizuka,Kellie L.K. Tamashiro,Frederick Nucifora,Vladimir M. Pogorelov,Bruce Ladenheim,Chunxia Yang,Irina N. Krasnova,Jean Lud Cadet,Carlos A. Pardo,Susumu Mori,Atsushi Kamiya,Michael W. Vogel,Akira Sawa,Christopher A. Ross,Mikhail V. Pletnikov +17 more
TL;DR: Prenatal immune activation interacted with mh DISC1 to produce the neurobehavioral phenotypes that were not seen in untreated mhDISC1 mice and that resemble aspects of major mental illnesses.
Journal ArticleDOI
Activity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks
Lavinia Alberi,Shuxi Liu,Yue Wang,Ramy Badie,Constance Smith-Hicks,Jing Wu,Tarran J. Pierfelice,Bagrat Abazyan,Mark P. Mattson,Mark P. Mattson,Dietmar Kuhl,Mikhail V. Pletnikov,Paul F. Worley,Nicholas Gaiano +13 more
TL;DR: Notch1 and its ligand Jagged1 are present at the synapse, and that Notch signaling in neurons occurs in response to synaptic activity, and neuronal NotCh signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity.
Journal ArticleDOI
Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders.
Yavuz Ayhan,Bagrat Abazyan,Jun Nomura,R Kim,Bruce Ladenheim,Irina N. Krasnova,Akira Sawa,Russell L. Margolis,Jean Lud Cadet,Susumu Mori,Michael W. Vogel,Christopher A. Ross,Mikhail V. Pletnikov +12 more
TL;DR: The data show that mutant hDISC1 exerts differential effects on neurobehavioral phenotypes, depending on the stage of development at which the protein is expressed.
Journal ArticleDOI
Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.
Ting Martin Ma,Sofya Abazyan,Bagrat Abazyan,Jun Nomura,C Yang,Saurav Seshadri,Akira Sawa,Solomon H. Snyder,Mikhail V. Pletnikov +8 more
TL;DR: Findings support a model wherein mutant DISC1 leads to SR degradation via dominant negative effects, resulting in D-serine deficiency that diminishes NMDA neurotransmission thus linking DISC 1 and NMDA pathophysiological mechanisms in mental illness.
Journal ArticleDOI
Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration
Steven M. Frank,Bagrat Abazyan,Masahiro Ono,Charles W. Hogue,David B. Cohen,Dan E. Berkowitz,Paul M. Ness,Viachaslau Barodka +7 more
TL;DR: It is demonstrated that increased duration of erythrocyte storage is associated with decreased cell membrane deformability and that these changes are not readily reversible after transfusion.