L
Luis Arnes
Researcher at Columbia University
Publications - 23
Citations - 1116
Luis Arnes is an academic researcher from Columbia University. The author has contributed to research in topics: Cancer & Glucose transporter. The author has an hindex of 15, co-authored 21 publications receiving 959 citations. Previous affiliations of Luis Arnes include Columbia University Medical Center & University of Copenhagen.
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Journal ArticleDOI
Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes
Ignasi Moran,Ildem Akerman,Martijn van de Bunt,Martijn van de Bunt,Ruiyu Xie,Marion Benazra,Takao Nammo,Luis Arnes,Nikolina Nakic,Javier García-Hurtado,Santiago A. Rodríguez-Seguí,Lorenzo Pasquali,Claire Sauty-Colace,Anthony Beucher,Raphael Scharfmann,Joris van Arensbergen,Paul Johnson,Paul Johnson,Andrew Berry,Clarence Lee,Timothy T. Harkins,Valery Gmyr,François Pattou,Julie Kerr-Conte,Lorenzo Piemonti,Thierry Berney,Neil A. Hanley,Anna L. Gloyn,Lori Sussel,Linda Langman,Kenneth L. Brayman,Maike Sander,Mark I. McCarthy,Mark I. McCarthy,Philippe Ravassard,Jorge Ferrer,Jorge Ferrer +36 more
TL;DR: A comprehensive strand-specific transcriptome map of human pancreatic islets and β cells is reported, and a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology are revealed.
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βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function
TL;DR: It is demonstrated that βlinc1 (β-cell long intergenic noncoding RNA 1), a conserved lncRNA, is necessary for the specification and function of insulin-producing β cells through the coordinated regulation of a number of islet-specific transcription factors located in the genomic vicinity of βlincoln1.
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Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population.
TL;DR: These studies provide evidence that many of hormone-producing cells within the adult islet represent heterogeneous populations based on their ontogeny, which could have broader implications on the regulation of islet cell ratios and their ability to effectively respond to fluctuations in the metabolic environment during development.
Journal ArticleDOI
Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression
Teresa L. Mastracci,Crystal L. Wilcox,Luis Arnes,Casandra Panea,Jeffrey A. Golden,Catherine Lee May,Lori Sussel +6 more
TL;DR: Novel genetic interactions are identified between Nkx2.2 and Arx within the endocrine progenitor cells that ensure the correct specification and regulation of endocrine hormone-producing cells.
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Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma.
Luis Arnes,Zhaoqi Liu,Jiguang Wang,Carlo Maurer,Irina Sagalovskiy,Marta Sanchez-Martin,Nikhil Bommakanti,Diana C. Garofalo,Dina A. Balderes,Lori Sussel,Kenneth P. Olive,Raul Rabadan +11 more
TL;DR: The findings indicate that lncRNAs are associated with genetic marks of pancreatic cancer risk, contribute to the transcriptional regulation of neoplastic cells and provide an important resource to design functional studies of lnc RNAs in PDA.