V
Vinee Purohit
Researcher at University of Michigan
Publications - 25
Citations - 1874
Vinee Purohit is an academic researcher from University of Michigan. The author has contributed to research in topics: Pancreatic cancer & Cancer cell. The author has an hindex of 12, co-authored 23 publications receiving 1206 citations. Previous affiliations of Vinee Purohit include University of Nebraska Medical Center & New York University.
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Journal ArticleDOI
Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Michael A. Badgley,Daniel M. Kremer,H. Carlo Maurer,H. Carlo Maurer,Kathleen E. DelGiorno,Ho-Joon Lee,Vinee Purohit,Irina Sagalovskiy,Alice Ma,Jonathan Kapilian,Christina E. M. Firl,Amanda R. Decker,Steve A. Sastra,Carmine F. Palermo,Leonardo R. Andrade,Peter Sajjakulnukit,Li Zhang,Zachary P. Tolstyka,Tal Hirschhorn,Candice Lamb,Tong Liu,Wei Gu,E. Scott Seeley,Everett Stone,George Georgiou,Uri Manor,Alina Iuga,Geoffrey M. Wahl,Brent R. Stockwell,Costas A. Lyssiotis,Kenneth P. Olive +30 more
TL;DR: This work shows that the import of oxidized cysteine (cystine) via system xC– is a critical dependency of pancreatic ductal adenocarcinoma (PDAC), which is a leading cause of cancer mortality.
Journal ArticleDOI
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.
Surendra K. Shukla,Vinee Purohit,Kamiya Mehla,Venugopal Gunda,Nina V. Chaika,Enza Vernucci,Ryan J. King,Jaime Abrego,Gennifer D. Goode,Aneesha Dasgupta,Alysha L. Illies,Teklab Gebregiworgis,Bingbing Dai,Jithesh J. Augustine,Divya Murthy,Kuldeep S. Attri,Oksana Mashadova,Paul M. Grandgenett,Robert Powers,Quan P. Ly,Audrey J. Lazenby,Jean L. Grem,Fang Yu,José M. Matés,John M. Asara,Jung Whan Kim,Jordan Hankins,Colin D. Weekes,Michael A. Hollingsworth,Natalie J. Serkova,Aaron R. Sasson,Jason B. Fleming,Jennifer M. Oliveto,Costas A. Lyssiotis,Lewis C. Cantley,Lyudmyla Berim,Pankaj K. Singh,Pankaj K. Singh +37 more
TL;DR: A widely prevalent mechanism of resistance to gemcitabine in pancreatic cancer is established, whereby increased glycolytic flux leads to glucose addiction in cancer cells and a corresponding increase in pyrimidine biosynthesis to enhance the intrinsic levels of deoxycytidine triphosphate (dCTP).
Journal ArticleDOI
Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia
Surendra K. Shukla,Teklab Gebregiworgis,Vinee Purohit,Vinee Purohit,Nina V. Chaika,Venugopal Gunda,Prakash Radhakrishnan,Kamiya Mehla,Iraklis I. Pipinos,Robert Powers,Fang Yu,Pankaj K. Singh +11 more
TL;DR: The studies demonstrate that the cachectic phenotype is in part due to metabolic alterations in tumor cells, which can be reverted by a ketogenic diet, causing reduced tumor growth and inhibition of muscle and body weight loss.
Journal ArticleDOI
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer
Nina V. Chaika,Teklab Gebregiworgis,Michelle E. Lewallen,Vinee Purohit,Prakash Radhakrishnan,Xiang Liu,Bo Zhang,Kamiya Mehla,Roger B. Brown,Thomas C. Caffrey,Fang Yu,Keith R. Johnson,Robert Powers,Michael A. Hollingsworth,Pankaj K. Singh +14 more
TL;DR: It is demonstrated that MUC1, a large, type I transmembrane protein that is overexpressed in several carcinomas including pancreatic adenocarcinoma, modulates cancer cell metabolism to facilitate growth properties of cancer cells.
Journal ArticleDOI
Graviola: A novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism
María P. Torres,Satyanarayana Rachagani,Vinee Purohit,Poomy Pandey,Suhasini Joshi,Erik D. Moore,Sonny L. Johansson,Pankaj K. Singh,Apar Kishor Ganti,Surinder K. Batra +9 more
TL;DR: Overall, the compounds that are naturally present in a Graviola extract inhibited multiple signaling pathways that regulate metabolism, cell cycle, survival, and metastatic properties in PC cells, indicating promising characteristics of the natural product against this lethal disease.