K
Kathleen E. DelGiorno
Researcher at Salk Institute for Biological Studies
Publications - 35
Citations - 2424
Kathleen E. DelGiorno is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 23 publications receiving 1582 citations. Previous affiliations of Kathleen E. DelGiorno include Stony Brook University & Mayo Clinic.
Papers
More filters
Journal ArticleDOI
Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Michael A. Badgley,Daniel M. Kremer,H. Carlo Maurer,H. Carlo Maurer,Kathleen E. DelGiorno,Ho-Joon Lee,Vinee Purohit,Irina Sagalovskiy,Alice Ma,Jonathan Kapilian,Christina E. M. Firl,Amanda R. Decker,Steve A. Sastra,Carmine F. Palermo,Leonardo R. Andrade,Peter Sajjakulnukit,Li Zhang,Zachary P. Tolstyka,Tal Hirschhorn,Candice Lamb,Tong Liu,Wei Gu,E. Scott Seeley,Everett Stone,George Georgiou,Uri Manor,Alina Iuga,Geoffrey M. Wahl,Brent R. Stockwell,Costas A. Lyssiotis,Kenneth P. Olive +30 more
TL;DR: This work shows that the import of oxidized cysteine (cystine) via system xC– is a critical dependency of pancreatic ductal adenocarcinoma (PDAC), which is a leading cause of cancer mortality.
Journal ArticleDOI
EGF Receptor is Required for KRAS-induced Pancreatic Tumorigenesis
Christine M. Ardito,Barbara M. Grüner,Kenneth K. Takeuchi,Clara Lubeseder-Martellato,Nicole Teichmann,Pawel K. Mazur,Kathleen E. DelGiorno,Kathleen E. DelGiorno,Eileen S. Carpenter,Christopher J. Halbrook,Christopher J. Halbrook,Jason C. Hall,Jason C. Hall,Debjani Pal,Thomas Briel,Alexander Herner,Marija Trajkovic-Arsic,Bence Sipos,Geou Yarh Liou,Peter Storz,Nicole R. Murray,David W. Threadgill,Maria Sibilia,M. Kay Washington,Carole L. Wilson,Roland M. Schmid,Elaine W. Raines,Howard C. Crawford,Howard C. Crawford,Howard C. Crawford,Jens T. Siveke +30 more
TL;DR: It is shown that oncogenic KRAS upregulates endogenous EGFR expression and activation, the latter being dependent on the EGFR ligand sheddase, ADAM17, which effectively eliminates KRAS-driven tumorigenesis in vivo.
Journal ArticleDOI
Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring
Yu Shi,Weina Gao,Nikki K. Lytle,Peiwu Huang,Peiwu Huang,Xiao Yuan,Amanda M. Dann,Maya Ridinger-Saison,Kathleen E. DelGiorno,Corina E. Antal,Gaoyang Liang,Annette R. Atkins,Galina Erikson,Huaiyu Sun,Jill Meisenhelder,Elena Terenziani,Gyunghwi Woo,Linjing Fang,Thom P. Santisakultarm,Uri Manor,Ruilian Xu,Carlos Becerra,Erkut Borazanci,Daniel D. Von Hoff,Paul M. Grandgenett,Michael A. Hollingsworth,Mathias Leblanc,Sarah E. Umetsu,Eric A. Collisson,Miriam Scadeng,Andrew M. Lowy,Timothy R. Donahue,Tannishtha Reya,Michael Downes,Ronald M. Evans,Geoffrey M. Wahl,Tony Pawson,Tony Pawson,Ruijun Tian,Ruijun Tian,Tony Hunter +40 more
TL;DR: A systematic proteomic investigation of disease mediators secreted by pancreatic stellate cells identifies leukaemia inhibitory factor (LIF) as a key factor that acts on cancer cells, promoting tumour progression and chemoresistance.
Journal ArticleDOI
Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions
Geou Yarh Liou,Heike Döppler,Kathleen E. DelGiorno,Lizhi Zhang,Michael Leitges,Howard C. Crawford,Michael P. Murphy,Peter Storz +7 more
TL;DR: It is shown that mutant KRas alters mitochondrial metabolism in pancreatic acinar cells, resulting in increased generation of mitochondrial reactive oxygen species (mROS), which drives the dedifferentiation of acinar Cells to a duct-like progenitor phenotype and progression to PanIN.
Journal ArticleDOI
RUNX3 controls a metastatic switch in pancreatic ductal adenocarcinoma
Martin C. Whittle,Kamel Izeradjene,P. Geetha Rani,Libing Feng,Markus A. Carlson,Kathleen E. DelGiorno,Laura D. Wood,Michael Goggins,Ralph H. Hruban,Amy Chang,Philamer Calses,Shelley M. Thorsen,Sunil R. Hingorani,Sunil R. Hingorani +13 more
TL;DR: Runx3 serves as both a tumor suppressor and promoter in slowing proliferation while orchestrating a metastatic program to stimulate cell migration, invasion, and secretion of proteins that favor distant colonization.