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Iris Cheung
Researcher at University of Massachusetts Medical School
Publications - 11
Citations - 868
Iris Cheung is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Prefrontal cortex & Epigenetics. The author has an hindex of 9, co-authored 11 publications receiving 769 citations.
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Journal ArticleDOI
Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex
Iris Cheung,Hennady P. Shulha,Yan Jiang,Anouch Matevossian,Jie Wang,Zhiping Weng,Zhiping Weng,Schahram Akbarian +7 more
TL;DR: It is demonstrated that H3K4me3 in human PFC is highly regulated in a cell type- and subject-specific manner and the importance of early childhood for developmentally regulated chromatin remodeling in prefrontal neurons is highlighted.
Journal ArticleDOI
Epigenetic Signatures of Autism: Trimethylated H3K4 Landscapes in Prefrontal Neurons
Hennady P. Shulha,Iris Cheung,Catheryne Whittle,Jie Wang,Daniel Virgil,Cong L. Lin,Yin Guo,Andree Lessard,Schahram Akbarian,Zhiping Weng +9 more
TL;DR: Prefrontal cortex neurons from subjects with autism show changes in chromatin structures at hundreds of loci genome-wide, revealing considerable overlap between genetic and epigenetic risk maps of developmental brain disorders.
Journal ArticleDOI
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons.
Hennady P. Shulha,Jessica L. Crisci,Denis A. Reshetov,Jogender S. Tushir,Iris Cheung,Rahul Bharadwaj,Hsin-Jung Chou,Isaac B. Houston,Cyril J. Peter,Amanda C. Mitchell,Wei-Dong Yao,Richard H. Myers,Jiang-Fan Chen,Todd M. Preuss,Evgeny I. Rogaev,Evgeny I. Rogaev,Jeffrey D. Jensen,Jeffrey D. Jensen,Zhiping Weng,Schahram Akbarian,Schahram Akbarian +20 more
TL;DR: Mapping histone methylation landscapes in neurons from human, chimpanzee, and macaque brains reveals coordinated, human-specific epigenetic regulation at hundreds of regulatory sequences.
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Neuronal Kmt2a/Mll1 Histone Methyltransferase Is Essential for Prefrontal Synaptic Plasticity and Working Memory
Mira Jakovcevski,Hongyu Ruan,Erica Y. Shen,Aslihan Dincer,Behnam Javidfar,Qi Ma,Cyril J. Peter,Iris Cheung,Amanda C. Mitchell,Yan Jiang,Cong L. Lin,Venu Pothula,A. Francis Stewart,Patricia Ernst,Wei-Dong Yao,Schahram Akbarian,Schahram Akbarian +16 more
TL;DR: Mature prefrontal neurons critically depend on maintenance of Mll1-regulated H3K4 methylation at a subset of genes with an essential role in cognition and emotion, including the homeodomain transcription factor Meis2.
Journal ArticleDOI
Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice☆
Erica Y. Shen,Todd H. Ahern,Iris Cheung,Juerg R. Straubhaar,Aslihan Dincer,Isaac B. Houston,Geert J. De Vries,Schahram Akbarian,Nancy G. Forger +8 more
TL;DR: Preliminary analyses on the genome-wide distribution of histone-3 lysine-4 trimethylation in a sexually dimorphic brain region in male and female mice indicate that genes and loci with increased H3K4me3 in females are associated with synaptic function and with expression atlases from related brain areas.