Isao Hamaguchi

TL;DR: In vitro study revealed that Adhesion of TIE2+ cells induced by Angiopoietin-1 enhanced the proliferation of hematopoietic progenitor cells and promoted the adhesion to fibronectin (FN) through integrins in Tie2-transfected cells and primary TIE1+ cells sorted from 9.5 d.p.c. P-Sp.

TL;DR: Characterization of two novel genes of their full-length cDNA sequences revealed that they were mouse homologues of the endothelial cell RTK genes, TIE and TEK, which shared a unique structural property of coexistent immunoglobulin-like domain, epidermal growth factor-like repeats, and fibronectin type III repeats in their extracellular domains.

TL;DR: This in vitro coculture system shows that the TEK+ fraction of primary AGM cells is a candidate for hemangioblasts, which can differentiate into both hematopoietic cells and endothelial cells.

TL;DR: The findings in this study are the first to indicate a new biological activity of Gas6 and protein S as a direct regulator of osteoclastic function; they give an insight into the role of these vitamin K‐dependent ligands in bone resorption in vivo.

TL;DR: Results suggest that Chk, but not Csk, may function as a translocation‐controlled negative regulator of CD36‐anchored Lyn in thrombin‐induced platelet activation.