J
J. Arjan G. M. de Visser
Researcher at Wageningen University and Research Centre
Publications - 81
Citations - 6400
J. Arjan G. M. de Visser is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Population & Fitness landscape. The author has an hindex of 32, co-authored 73 publications receiving 5685 citations. Previous affiliations of J. Arjan G. M. de Visser include Michigan State University.
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Journal ArticleDOI
Perspective: Evolution and detection of genetic robustness.
J. Arjan G. M. de Visser,Joachim Hermisson,Günter P. Wagner,Lauren Ancel Meyers,Homayoun Bagheri-Chaichian,Jeffrey L. Blanchard,Lin Chao,James M. Cheverud,Santiago F. Elena,Walter Fontana,Greg Gibson,Thomas F. Hansen,David C. Krakauer,Richard C Lewontin,Charles Ofria,Sean H. Rice,George von Dassow,Andreas Wagner,Michael C. Whitlock +18 more
TL;DR: This work focuses on the first kind of robustness—genetic robustness)—and survey three growing avenues of research: measuring genetic robustness in nature and in the laboratory; understanding the evolution of genetic robusts; and exploring the implications of genetic resilientness for future evolution.
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Empirical fitness landscapes and the predictability of evolution
TL;DR: This work reviews recent empirical and theoretical developments of the genotype–fitness map, identifies methodological issues and organizing principles, and discusses possibilities to develop more realistic fitness landscape models.
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The Host Genotype Affects the Bacterial Community in the Human Gastrointestinal Tract
Erwin G. Zoetendal,Antoon D. L. Akkermans,Wilma M. Akkermans-van Vliet,J. Arjan G. M. de Visser,Willem M. de Vos +4 more
TL;DR: The data indicate that factors related to the host genotype have an important effect on determining the bacterial composition in the GI tract.
Journal ArticleDOI
The evolution of sex: empirical insights into the roles of epistasis and drift
TL;DR: New ideas about the evolution of sexual recombination are being tested, including intriguing suggestions of an important interplay between sex and genetic architecture, which indicate that sex and recombination could have affected their own evolution.
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Initial Mutations Direct Alternative Pathways of Protein Evolution
Merijn L. M. Salverda,Eynat Dellus,Florien A. Gorter,Alfons J. M. Debets,John van der Oost,Rolf F. Hoekstra,Dan S. Tawfik,J. Arjan G. M. de Visser +7 more
TL;DR: It is found that a combination of decreased enzymatic activity and lower folding cooperativity underlies negative sign epistasis in the clash between key mutations in the common and deviating lines, demonstrating that epistasis contributes to contingency in protein evolution by amplifying the selective consequences of random mutations.