J. B. Rimmler

TL;DR: A protective effect of the ε2 allele, in addition to the dose effect ofThe ε4 allele in sporadic AD, is demonstrated, which further support the direct involvement of APOE in the pathogenesis of AD.

TL;DR: It is concluded that the progression of AD is not strongly related to ε4 gene dose, that the higher prevalence of AD in women may involve the longer survival of affected women, and that AD and death are competing risks involving APOE that change over time.

TL;DR: The association of DR2 in families with different clinical presentations suggests that a common basis exists for susceptibility in multiple sclerosis, however, non-HLA genes or other epigenetic factors must modulate disease expression.

TL;DR: Using family-based association analysis, statistically significant evidence is found that an SNP haplotype near APOE is associated with MS susceptibility and an analysis of disease progression in 614 patients with MS from 379 families indicated that APOE-4 carriers are more likely to be affected with severe disease.

TL;DR: One of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk, which may indicate a possible protective function of the allele.