J
J. Christopher Love
Researcher at Massachusetts Institute of Technology
Publications - 215
Citations - 20681
J. Christopher Love is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 55, co-authored 186 publications receiving 17873 citations. Previous affiliations of J. Christopher Love include University of Illinois at Urbana–Champaign & Harvard University.
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Patent
Method for detecting active and latent virally infected cells
J. Christopher Love,Yuan Gong +1 more
TL;DR: In this article, the authors proposed methods for detecting virus production, determining frequency and identity of HIV reservoirs, or evaluating gene expression on a single-cell basis using microengraving and RT-PCR.
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Integrated process design for single‐cell analytical technologies
Journal ArticleDOI
A combined screening and in silico strategy for the rapid design of integrated downstream processes for process and product‐related impurity removal
Nicholas Vecchiarello,Steven M. Timmick,Chaz Goodwine,Laura E. Crowell,Kerry R. Love,J. Christopher Love,Steven M. Cramer +6 more
TL;DR: This approach suggests a new platform‐like approach for rapidly designing purification processes for a range of proteins where separations of both process‐ and product‐related impurities are needed.
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Rho/SMAD/mTOR triple inhibition enables long-term expansion of human neonatal tracheal aspirate-derived airway basal cell-like cells.
Junjie Lu,Xiaobo Zhu,Jessica E. Shui,Linjie Xiong,Todd M. Gierahn,Cheng Zhang,Michael A. Wood,Suzanne Hally,J. Christopher Love,Hu Li,Benjamin C. Crawford,Hongmei Mou,Paul H. Lerou +12 more
TL;DR: Using Rho/SMAD/mTOR triple signaling inhibition, neonatal tracheal aspirate-derived (nTAD) basal cell-like cells can be expanded long term and retain the ability to differentiate into pseudostratified airway epithelium.
Journal ArticleDOI
An impurity characterization based approach for the rapid development of integrated downstream purification processes.
Steven M. Timmick,Nicholas Vecchiarello,Chaz Goodwine,Laura E. Crowell,Kerry R. Love,J. Christopher Love,Steven M. Cramer +6 more
TL;DR: A new approach for the characterization of process‐related impurities along with an in silico tool to generate orthogonal, integrated downstream purification processes for biological products successfully demonstrated for the rapid development of robust integrated processes for human growth hormone and granulocyte‐colony stimulating factor.