J
J. Christopher Love
Researcher at Massachusetts Institute of Technology
Publications - 215
Citations - 20681
J. Christopher Love is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 55, co-authored 186 publications receiving 17873 citations. Previous affiliations of J. Christopher Love include University of Illinois at Urbana–Champaign & Harvard University.
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Posted ContentDOI
A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates
Neil C. Dalvie,Lisa H. Tostanoski,Sergio A. Rodriguez-Aponte,Kawaljit Kaur,Sakshi Bajoria,Ozan S. Kumru,Amanda J. Martinot,Amanda J. Martinot,Abishek Chandrashekar,Katherine McMahan,Noe B. Mercado,Jingyou Yu,Aiquan Chang,Aiquan Chang,Victoria M. Giffin,Felix Nampanya,Shivani A. Patel,Lesley Bowman,Christopher A Naranjo,Dongsoo Yun,Zach Flinchbaugh,Laurent Pessaint,Renita Brown,Jason Velasco,Elyse Teow,Anthony L. Cook,Hanne Leth Andersen,Mark G. Lewis,Danielle L Camp,Judith M. Silverman,Harry Kleanthous,Sangeeta B. Joshi,David B. Volkin,Sumi Biswas,J. Christopher Love,J. Christopher Love,Dan H. Barouch +36 more
TL;DR: In this article, the SARS-CoV-2 receptor binding domain (RBD) and hepatitis B surface antigen virus-like particles (VLPs) were used for preclinical testing in cynomolgus macaques.
Patent
Forming gel structures using microfluidic channels
TL;DR: In this paper, the use of spatially defined flows of fluid within micro-channels to form portions of gel (e.g., gel structures) inside the microchannels is described.
Journal ArticleDOI
Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor-binding domain in engineered Komagataella phaffii.
Neil C. Dalvie,Andrew M. Biedermann,Sergio A. Rodriguez-Aponte,Christopher A Naranjo,Harish D Rao,Meghraj P Rajurkar,Rakesh R Lothe,Umesh Shaligram,Ryan S Johnston,Laura E. Crowell,Seraphin Castelino,Mary Kate Tracey,Charles A. Whittaker,J. Christopher Love +13 more
TL;DR: In this article, an improved and scalable manufacturing approach for the SARS-CoV-2 spike protein receptor-binding domain (RBD) was reported, which is a key antigen for several reported vaccine candidates.
Journal ArticleDOI
Automated pipeline for rapid production and screening of HIV‐specific monoclonal antibodies using pichia pastoris
Kartik A. Shah,John J. Clark,Brittany A. Goods,Timothy J. Politano,Nicholas J. Mozdzierz,Ross M. Zimnisky,Rachel Leeson,J. Christopher Love,Kerry R. Love +8 more
TL;DR: This work has developed an automated pipeline for the rapid production and screening of full-length antigen-specific mAbs by combining the advantages of overlap extension PCR (OE-PCR) and a genetically stable yet easily manipulatable microbial expression host Pichia pastoris.
Journal ArticleDOI
Low protease activity in B cell follicles promotes retention of intact antigens after immunization
Aereas Aung,Ang Cui,Laura Maiorino,Ava Amini,Justin R. Gregory,M E E Bukenya,Yiming Zhang,Heya Lee,Christopher A. Cottrell,Duncan M. Morgan,Murillo Silva,Heikyung Suh,Jesse D. Kirkpatrick,Parastoo Amlashi,Tanaka Remba,Leah Froehle,Shuhao Xiao,Wuhbet Abraham,Josetta Adams,J. Christopher Love,Phillip Huyett,Douglas S. Kwon,Nir Hacohen,William R. Schief,Sangeeta N. Bhatia,Darrell J. Irvine +25 more
TL;DR: Aung et al. as mentioned in this paper found that antigens were rapidly degraded in the subcapsular sinus, paracortex and interfollicular regions, whereas low protease activity and antigen degradation rates were detected in the vicinity of follicular dendritic cells (FDCs).