J
J. Christopher Love
Researcher at Massachusetts Institute of Technology
Publications - 215
Citations - 20681
J. Christopher Love is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 55, co-authored 186 publications receiving 17873 citations. Previous affiliations of J. Christopher Love include University of Illinois at Urbana–Champaign & Harvard University.
Papers
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Proceedings ArticleDOI
Abstract 993: Whole exome sequencing of CTCs as a window into metastatic cancer
Viktor A. Adalsteinsson,Jens G. Lohr,Kristian Cibulskis,Atish D. Choudhury,Mara Rosenberg,Peter Cruz-Gordillo,Joshua M. Francis,Cheng-Zhong Zhang,Alex K. Shalek,Rahul Satija,John T. Trombetta,Diana Lu,Naren Tallapragada,Narmin Tahirova,Sora Kim,Brendan Blumenstiel,Carrie Sougnez,Daniel Auclair,Eliezer M. Van Allen,Mari Nakabayashi,Rosina T. Lis,Gwo-Shu Mary Lee,Tiantian Li,Matthew S. Chabot,Mary-Ellen Taplin,Thomas E. Clancy,Massimo Loda,Aviv Regev,Matthew Meyerson,William C. Hahn,Philip W. Kantoff,Todd R. Golub,Gad Getz,Jesse S. Boehm,J. Christopher Love +34 more
TL;DR: The feasibility of CTC sequencing and the ability to confidently call somatic mutations are demonstrated, and CTCs may represent a non-invasive window into the mutational landscape of metastatic cancer, and may have utility for genomics in clinical practice.
Journal ArticleDOI
Rapid optimization of processes for the integrated purification of biopharmaceuticals.
TL;DR: In this paper, the authors demonstrate a method for the development and optimization of fully integrated, multi-column processes for straight-through purification, where the eluate from one column passes directly onto another column without adjustment, and a two-step optimization was conducted to determine the buffer conditions that maximized yield while minimizing process- and product-related impurities.
Journal ArticleDOI
Tbio-18. liquid biopsy detection of genomic alterations in pediatric brain tumors from cell free dna in peripheral blood, csf, and urine
Melanie Pages,Denisse Rotem,Gregory Gydush,Sarah C. Reed,Justin Rhoades,Gavin Ha,Christopher Lo,Adam Tracy,Robert T. Jones,Sarah Becker,Michaela Haller,Susan N. Chi,Susan N. Chi,Mark W. Kieran,Mark W. Kieran,Liliana Goumnerova,Liliana Goumnerova,J. Christopher Love,Keith L. Ligon,Keith L. Ligon,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Karen Wright,Karen Wright,Viktor A. Adalsteinsson,Viktor A. Adalsteinsson,Rameen Beroukhim,Rameen Beroukhim +27 more
Patent
Systems and methods for manufacturing biologically-produced products
J. Christopher Love,Kerry R. Love,Laura E. Crowell,Alan Stockdale,Richard D. Braatz,Amos E. Lu,Steven M. Cramer,Steven Timmick,Nicholas Vecchiarello,Chaz Goodwine,Craig A. Mascarenhas +10 more
TL;DR: In this article, the authors describe an integrated biomanufacturing system with a bioreactor and at least one filter (e.g., a filter probe) integrated with a purification module comprising at least a first partitioning unit and two partitioning units.
Stochastic barcoding for single-cell tracking
TL;DR: Stochastic barcoding is presented, a method for tracking cell identity across analytical platforms that uses a randomly generated code based on number, color and position of beads encapsulated together with a set of cells of interest.