J
J. Christopher Love
Researcher at Massachusetts Institute of Technology
Publications - 215
Citations - 20681
J. Christopher Love is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 55, co-authored 186 publications receiving 17873 citations. Previous affiliations of J. Christopher Love include University of Illinois at Urbana–Champaign & Harvard University.
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Journal ArticleDOI
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells
Chih-Chi Andrew Hu,Stephanie K. Dougan,Annette M McGehee,J. Christopher Love,Hidde L. Ploegh +4 more
TL;DR: The role of XBP‐1 is defined in normal plasma cell development and have implications for management of B‐cell malignancies.
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TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage
Roslyn A Taylor,Roslyn A Taylor,Che-Feng Chang,Brittany A. Goods,Matthew D. Hammond,Matthew D. Hammond,Brian Mac Grory,Youxi Ai,Arthur F. Steinschneider,Stephen C. Renfroe,Michael H. Askenase,Louise D. McCullough,Scott E. Kasner,Michael T. Mullen,David A. Hafler,J. Christopher Love,Lauren H Sansing +16 more
TL;DR: The data show that TGF-&bgr;1 modulates microglia-mediated neuroinflammation after ICH and promotes functional recovery, suggesting that T GF- &b gr;1 may be a therapeutic target for acute brain injury.
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PD-1 marks dysfunctional regulatory T cells in malignant gliomas
Daniel E. Lowther,Brittany A. Goods,Liliana E. Lucca,Benjamin A. Lerner,Khadir Raddassi,David van Dijk,Amanda L. Hernandez,Xiangguo Duan,Murat Gunel,Vlad Coric,Smita Krishnaswamy,J. Christopher Love,David A. Hafler +12 more
TL;DR: High PD-1 expression on human Tregs identifies dysfunctional, exhausted T Regs secreting IFN-γ that exist in healthy individuals and are enriched in tumor infiltrates, possibly losing function as they attempt to modulate the antitumoral immune responses.
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Screening individual hybridomas by microengraving to discover monoclonal antibodies
Adebola O. Ogunniyi,Craig M. Story,Eli Papa,Eduardo Guillen,J. Christopher Love,J. Christopher Love +5 more
TL;DR: This protocol describes how to use microengraving to screen mouse hybridomas to establish new cell lines producing unique mAbs, a rapid and efficient alternative for discovering new monoclonal antibodies.
Journal ArticleDOI
Towards an in vivo biologically inspired nanofactory
Philip R. LeDuc,Michael S. Wong,Placid M. Ferreira,Richard E. Groff,Kiryn Haslinger,Michael P. Koonce,Woo Y. Lee,J. Christopher Love,J. Andrew McCammon,Nancy A. Monteiro-Riviere,Vincent M. Rotello,Gary W. Rubloff,Robert M. Westervelt,Minami Yoda +13 more
TL;DR: It may, however, be possible to go even further and design 'pseudo-cell' nanofactories that work with molecules already in the body to fight disease.