J
J. Christopher Love
Researcher at Massachusetts Institute of Technology
Publications - 215
Citations - 20681
J. Christopher Love is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 55, co-authored 186 publications receiving 17873 citations. Previous affiliations of J. Christopher Love include University of Illinois at Urbana–Champaign & Harvard University.
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Partitioning microfluidic channels with hydrogel to construct tunable 3-D cellular microenvironments.
TL;DR: A flexible method for creating a cellular microenvironment in vitro that allows controlled spatial distribution (patterning) of multiple types of cells within three-dimensional matrices of a biologically derived, thermally curable hydrogel (Matrigel) and application of gradients of soluble factors, such as cytokines, across the Hydrogel.
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Three-Dimensional Self-Assembly of Metallic Rods with Submicron Diameters Using Magnetic Interactions
TL;DR: This work provides a simple demonstration that magnetic interactions between ferromagnetic objects can direct and stabilize the formation of ordered, 3D structures by self-assembly.
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Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving
Qing Han,Elizabeth M. Bradshaw,Björn Nilsson,David A. Hafler,David A. Hafler,J. Christopher Love,J. Christopher Love +6 more
TL;DR: It is demonstrated that microengraving can provide quantitative measurements of both the frequencies and the distribution in rates of secretion for up to four cytokines simultaneously released from individual viable primary immune cells.
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In vivo discovery of immunotherapy targets in the tumour microenvironment
Penghui Zhou,Donald R. Shaffer,Diana A. Alvarez Arias,Yukoh Nakazaki,Wouter Pos,Alexis J. Torres,Viviana Cremasco,Stephanie K. Dougan,Glenn S. Cowley,Kutlu G. Elpek,Jennifer Brogdon,John Lamb,Shannon J. Turley,Hidde L. Ploegh,David E. Root,J. Christopher Love,Glenn Dranoff,Nir Hacohen,Harvey Cantor,Kai W. Wucherpfennig +19 more
TL;DR: Key regulators of immune function can be discovered in relevant tissue microenvironments through an in vivo pooled short hairpin RNA (shRNA) screen in which shRNAs targeting negative regulators became highly enriched in murine tumours by releasing a block on T-cell proliferation upon tumour antigen recognition.
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Cell-surface sensors for real-time probing of cellular environments
Weian Zhao,Sebastian Schafer,Jonghoon Choi,Yvonne J. Yamanaka,Maria L. Lombardi,Suman Bose,Alicia L. Carlson,Joseph A. Phillips,Weisuong Teo,Ilia A. Droujinine,Cheryl H. Cui,Rakesh K. Jain,Jan Lammerding,J. Christopher Love,Charles P. Lin,Debanjan Sarkar,Rohit Karnik,Jeffrey M. Karp +17 more
TL;DR: In this paper, an aptamer (a short length of single-stranded DNA) is attached to platelet-derived growth factor (PDGF) and contains a pair of fluorescent dyes.