J
J. Christopher Love
Researcher at Massachusetts Institute of Technology
Publications - 215
Citations - 20681
J. Christopher Love is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 55, co-authored 186 publications receiving 17873 citations. Previous affiliations of J. Christopher Love include University of Illinois at Urbana–Champaign & Harvard University.
Papers
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Journal ArticleDOI
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.
Michael H. Askenase,Brittany A. Goods,Hannah E. Beatty,Arthur F. Steinschneider,Sofia E. Velazquez,Artem Osherov,Margaret J. Landreneau,Shaina Carroll,Tho B. Tran,Victor S. Avram,Riley S. Drake,G. James Gatter,Jordan Massey,Saravanan S. Karuppagounder,Rajiv R. Ratan,Charles C. Matouk,Kevin N. Sheth,Wendy C. Ziai,Adrian R Parry-Jones,Issam A. Awad,Mario Zuccarello,Richard E. Thompson,Jesse Dawson,Daniel F. Hanley,J. Christopher Love,J. Christopher Love,Alex K. Shalek,Lauren H Sansing,ICHseq investigators +28 more
TL;DR: In this paper, a clinical trial of minimally invasive neurosurgery for patients with intracerebral hemorrhage (ICH), a severely disabling subtype of stroke, was used to investigate the dynamics of inflammation at the site of brain injury over time.
Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines
Viktor A. Adalsteinsson,Narmin Tahirova,Naren Tallapragada,Xiaosai Yao,Liam Campion,Alessandro Angelini,Thomas B. Douce,Brittany A. Bowman,Christina A. Williamson,J. Christopher Love,Cindy Huang,Douglas S. Kwon,Karl Dane Wittrup +12 more
TL;DR: The secretions of ELR+CXC chemokines from thousands of single colorectal tumor and stromal cells, using an array of subnanoliter wells and a technique called microengraving to characterize both the rates of secretion of several factors at once and the numbers of cells secreting each chemokine.
Patent
Systems, methods, and apparatus for in vitro single-cell identification and recovery
TL;DR: In this paper, the authors present systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid.
Journal ArticleDOI
SARS-CoV-2 receptor binding domain displayed on HBsAg virus–like particles elicits protective immunity in macaques
Neil C. Dalvie,Lisa H. Tostanoski,Sergio A. Rodriguez-Aponte,Kawaljit Kaur,S Bajoria,Ozan S. Kumru,Amanda J. Martinot,Abishek Chandrashekar,Katherine McMahan,Noe B. Mercado,Jingyou Yu,Aiquan Chang,Victoria M. Giffin,Felix Nampanya,Shivani A. Patel,Lesley A.H. Bowman,C. A. Naranjo,Dongsoo Yun,Zach Flinchbaugh,Laurent Pessaint,Renita Brown,Jason Velasco,Elyse Teow,Anthony Cook,Hanne Andersen,Mark A. Lewis,Danielle L. Camp,Judith M. Silverman,Gaurav S Nagar,Harish D Rao,Rakesh R. Lothe,Rahul Chandrasekharan,Meghraj P. Rajurkar,Umesh Shaligram,Harry Kleanthous,Sangeeta B. Joshi,David B. Volkin,Sumi Biswas,J. Christopher Love,Dan H. Barouch +39 more
TL;DR: Here, a clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain–hepatitis B surface antigen virus–like particle elicited protective immunity in cynomolgus macaques, and the potential benefit of this design for a low-cost modular vaccine platform is supported.
Tumor cells are dislodged into the pulmonary vein during lobectomy
Xiaosai Yao,Christina Williamson,Richard S. D’Agostino,Torin P. Fitton,Gregory G. Smaroff,Robert T. William,J. Christopher Love,Viktor A. Adalsteinsson,Karl Dane Wittrup +8 more
TL;DR: Surgery mobilizes tumor cells into the pulmonary vein, along with many normal epithelial cells, and single-cell genetic approaches with patient-matched normal and tumor tissues can accurately quantify the number of shed tumor cells.