J
J. Christopher Love
Researcher at Massachusetts Institute of Technology
Publications - 215
Citations - 20681
J. Christopher Love is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 55, co-authored 186 publications receiving 17873 citations. Previous affiliations of J. Christopher Love include University of Illinois at Urbana–Champaign & Harvard University.
Papers
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Journal ArticleDOI
Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines
Viktor A. Adalsteinsson,Viktor A. Adalsteinsson,Narmin Tahirova,Narmin Tahirova,Naren Tallapragada,Xiaosai Yao,Liam Campion,Alessandro Angelini,Thomas B. Douce,Cindy Huang,Brittany A. Bowman,Christina A. Williamson,Douglas S. Kwon,K. Dane Wittrup,J. Christopher Love +14 more
TL;DR: This study reveals new insight into the intratumoral phenotypic heterogeneity of human primary tumors, and finds that human primary colorectal tumor and stromal cells exhibit polyfunctional heterogeneity in the combinations and magnitudes of secretions for these chemokines.
Proceedings ArticleDOI
Control systems technology in the advanced manufacturing of biologic drugs
Amos E. Lu,Joel A. Paulson,Nicholas J. Mozdzierz,Alan Stockdale,Ashlee N. Ford Versypt,Kerry R. Love,J. Christopher Love,Richard D. Braatz +7 more
TL;DR: This paper presents models and control strategies for the unit operations within the InSCyT platform, including a perfusion bioreactor, several packed bed and membrane chromatography steps, and a conductivity- and pH-controlled buffer mixing unit.
Journal ArticleDOI
Electroforming of copper structures at nanometer-sized gaps of self-assembled monolayers on silver
TL;DR: In this paper, a method to fabricate micro-and nanostructures of copper by electrodeposition onto nanometer-sized gaps in self-assembled monolayers (SAM) of alkanethiolates on metal surfaces is described.
Journal Article
Cell-surface sensors for real-time probing of cellular environments
Weian Zhao,Sebastian Schafer,Jonghoon Choi,Yvonne J. Yamanaka,Maria L. Lombardi,Suman Bose,Alicia L. Carlson,Joseph A. Phillips,Weisuong Teo,Ilia A. Droujinine,Cheryl H. Cui,Rakesh K. Jain,Jan Lammerding,J. Christopher Love,Charles P. Lin,Debanjan Sarkar,Rohit Karnik,Jeffrey M. Karp +17 more
TL;DR: A fluorescent sensor attached to a cell membrane can detect signalling molecules in the cellular environment and can quantitatively detect with high spatial and temporal resolution PDGF that is added in cell culture medium or secreted by neighbouring cells.
Journal ArticleDOI
Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity
Brittany L. Hartwell,Mariane B. Melo,Peng Xiao,Ashley A. Lemnios,Na Li,Jason Y. Chang,Jingyou Yu,Makda S. Gebre,Aiquan Chang,Laura Maiorino,Crystal Spruill Carter,Tyson J. Moyer,Neil C. Dalvie,Sergio A. Rodriguez-Aponte,Kristen A. Rodrigues,Murillo Silva,Heikyung Suh,Josetta Adams,Jane Fontenot,J. Christopher Love,Dan H. Barouch,Francois Villinger,Ruth M. Ruprecht,Darrell J. Irvine +23 more
TL;DR: It is suggested that using amph-protein vaccines to deliver antigen across mucosal epithelia is a promising strategy to promote mucosal immunity against HIV, SARS-CoV-2, and other infectious diseases.