J. K. H. Rees

TL;DR: Subgroup analysis demonstrated that the three cytogenetically defined prognostic groups retained their predictive value in the context of secondary as well as de novo AML, within the pediatric age group and furthermore were found to be a key determinant of outcome from autologous or allogeneic bone marrow transplantation (BMT) in first CR.

TL;DR: The addition of autologous BMT to four courses of intensive chemotherapy substantially reduces the risk of relapse in all risk groups, leading to improvement in long-term survival.

TL;DR: In this article, the MRC AML 10 trial data were used to create a prognostic index for use in risk-directed therapy decision-making for younger patients with acute myeloid leukaemia (AML).

TL;DR: In most cases the existence of the translocation was predicted from the cytological and cytochemical findings, and to a lesser extent with periodic acid‐Schiff and chloroacetate esterase.

TL;DR: Reverse transcription coupled with the polymerase chain reaction (RT‐PCR) has been used to develop a diagnostic test for APL based on the PML‐RARA fusion message, which suggests that it is the 15q + derivative which mediates leukaemogenesis.