J
Jacov Levy
Researcher at Ben-Gurion University of the Negev
Publications - 70
Citations - 3083
Jacov Levy is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Congenital insensitivity to pain with anhidrosis & Congenital insensitivity to pain. The author has an hindex of 25, co-authored 70 publications receiving 2856 citations. Previous affiliations of Jacov Levy include Barzilai Medical Center & Soroka Medical Center.
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Journal ArticleDOI
Clinical spectrum of X-linked hyper-IgM syndrome
Jacov Levy,Teresa Espanol-Boren,Carolin Thomas,Alain Fischer,Pier-Angelo Tovo,Pierre Bordigoni,Igor B. Resnick,Anders Fasth,Maija Baer,Lina Gomez,E.A.M. Sanders,Marie-Dominique Tabone,Dominique Plantaz,Amos Etzioni,V. Monafo,Mario Abinun,Lennart Hammarström,Tore G. Abrahamsen,Allison Jones,Adam Finn,Timo Klemola,Esther DeVries,Ozden Sanal,Manuel C. Peitsch,Luigi D. Notarangelo +24 more
TL;DR: Although lymphocyte counts and in vitro proliferation to mitogens were normal, a defective in vitro proliferative response to antigens was observed in some patients, and additional defects of cell-mediated immunity may be presumed on the basis of current knowledge of CD40-ligand function.
Journal Article
Cholangiopathy and tumors of the pancreas, liver, and biliary tree in boys with X-linked immunodeficiency with hyper-IgM.
Anthony R. Hayward,Jacov Levy,Fabio Facchetti,Luigi D. Notarangelo,Hans D. Ochs,Amos Etzioni,Jean Yves Bonnefoy,Mary Cosyns,Adriana Weinberg +8 more
TL;DR: It is proposed that the CD40 ligand mutations that cause XHIM deprive the biliary epithelium of one line of defense against intracellular pathogens and that malignant transformation in the bile ducts follows chronic infection or inflammation.
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Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to Activation-Induced Cytidine Deaminase deficiency
Pierre Quartier,Jacinta Bustamante,Ozden Sanal,Alessandro Plebani,Marianne Debré,Anne Deville,Jiri Litzman,Jacov Levy,Jean-Paul Fermand,Peter J. L. Lane,Gerd Horneff,Guzide Aksu,Işık Yalçın,Graham Davies,Ilhan Tezcan,Ersoy F,Nadia Catalan,Kohsuhe Imai,Alain Fischer,Anne Durandy +19 more
TL;DR: AID-deficient patients are prone to infections and lymphoid hyperplasia, which may be prevented by early-onset IVIG replacement, but also to autoimmune and inflammatory disorders.
Journal ArticleDOI
A review of anti-VEGF agents for proliferative diabetic retinopathy.
TL;DR: Off-label use of anti-VEGF agents was found to be beneficial in PDR, especially in cases with neovascular glaucoma, persistent vitreous haemorrhage, and before vitrectomy.
Journal ArticleDOI
Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: Genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies
Sharon Shatzky,Shimon Moses,Jacov Levy,Vered Pinsk,Eli Hershkovitz,Laura Herzog,Zamir Shorer,Anthony Luder,Ruti Parvari +8 more
TL;DR: Using the linkage analysis approach, the disease was linked in 9 of 10 unrelated Israeli-Bedouin families with CIPA to the TrkA gene, which encodes the receptor for nerve growth factor, and two new mutations in the tyrosine kinase domain were identified in patients.