G
Graham Davies
Researcher at Great Ormond Street Hospital
Publications - 36
Citations - 3606
Graham Davies is an academic researcher from Great Ormond Street Hospital. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 21, co-authored 36 publications receiving 3385 citations. Previous affiliations of Graham Davies include Boston Children's Hospital & National Health Service.
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Journal ArticleDOI
Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968–99
Corinne Antoine,Susanna M. Müller,Andrew J. Cant,Marina Cavazzana-Calvo,Paul Veys,Jaak M. Vossen,Anders Fasth,Carsten Heilmann,NM Wulffraat,Reinhard Seger,Stéphane Blanche,Wilhelm Friedrich,Mario Abinun,Graham Davies,Robert Bredius,Ansgar Schulz,Paul Landais,Alain Fischer +17 more
TL;DR: The improvement in survival over time indicates more effective prevention and treatment of disease-related and procedure-related complications and graft versus host disease in the HLA-non-identical setting by use of more efficient methods of T-cell depletion.
Journal ArticleDOI
C1 inhibitor deficiency: consensus document
Mark Gompels,Robert J Lock,Mario Abinun,Claire Bethune,Graham Davies,C. Grattan,A. C. Fay,H. J. Longhurst,L. Morrison,A. Price,M. Price,D. Watters +11 more
TL;DR: A consensus document on the diagnosis and management of C1 inhibitor deficiency, a syndrome characterized clinically by recurrent episodes of angio‐oedema, which can cause fatal laryngeal oedema and features indistinguishable from gastrointestinal tract obstruction is presented.
Journal ArticleDOI
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88
Bing He,Raul Santamaria,Weifeng Xu,Montserrat Cols,Kang Chen,Irene Puga,Meimei Shan,Huabao Xiong,James B. Bussel,April Chiu,Anne Puel,Jeanine Reichenbach,László Maródi,Rainer Doffinger,Júlia Vasconcelos,Andrew C. Issekutz,Jens C. Krause,Graham Davies,Xiaoxia Li,Bodo Grimbacher,Alessandro Plebani,Eric Meffre,Capucine Picard,Charlotte Cunningham-Rundles,Jean-Laurent Casanova,Jean-Laurent Casanova,Andrea Cerutti,Andrea Cerutti +27 more
TL;DR: The cytoplasmic domain of TACI encompasses a conserved motif that bound MyD88, an adaptor that activates transcription factor NF-κB signaling pathways via a Toll–interleukin 1 (IL-1) receptor (TIR) domain, which indicates that MyD 88 controls a B cell–intrinsic, TIR-independent, TACi-dependent pathway for immunoglobulin diversification.
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Low Penetrance, Broad Resistance, and Favorable Outcome of Interleukin 12 Receptor β1 Deficiency Medical and Immunological Implications
Claire Fieschi,Stéphanie Dupuis,Emilie Catherinot,Jacqueline Feinberg,Jacinta Bustamante,Adrien Breiman,Frédéric Altare,Richard Baretto,Françoise Le Deist,Samer Kayal,Hartmut Koch,Darko Richter,Martin Brezina,Guzide Aksu,Phil Wood,Suliman Al-Jumaah,Miquel Raspall,Alberto José da Silva Duarte,David Tuerlinckx,Jean Louis Virelizier,Alain Fischer,Andrea M. Enright,Jutta Bernhöft,Aileen M. Cleary,Christiane Vermylen,Carlos Rodríguez-Gallego,Graham Davies,Renate Blütters-Sawatzki,Claire-Anne Siegrist,Mohammad S. Ehlayel,Vas Novelli,Walther H. Haas,Walther H. Haas,Jacob Levy,Joachim Freihorst,Sami Al-Hajjar,David Nadal,Dewton de Moraes Vasconcelos,Olle Jeppsson,Necil Kutukculer,Klara Frecerova,Isabel Caragol,David A. Lammas,Dinakantha S. Kumararatne,Laurent Abel,Jean-Laurent Casanova +45 more
TL;DR: A diagnosis of IL-12Rβ1 deficiency should be considered in children with opportunistic mycobacteriosis or salmonellosis; healthy siblings of probands and selected cases of tuberculosis should also be investigated.
Journal ArticleDOI
Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to Activation-Induced Cytidine Deaminase deficiency
Pierre Quartier,Jacinta Bustamante,Ozden Sanal,Alessandro Plebani,Marianne Debré,Anne Deville,Jiri Litzman,Jacov Levy,Jean-Paul Fermand,Peter J. L. Lane,Gerd Horneff,Guzide Aksu,Işık Yalçın,Graham Davies,Ilhan Tezcan,Ersoy F,Nadia Catalan,Kohsuhe Imai,Alain Fischer,Anne Durandy +19 more
TL;DR: AID-deficient patients are prone to infections and lymphoid hyperplasia, which may be prevented by early-onset IVIG replacement, but also to autoimmune and inflammatory disorders.