J
Jacques A. Nunès
Researcher at Aix-Marseille University
Publications - 86
Citations - 4127
Jacques A. Nunès is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: T cell & CD28. The author has an hindex of 29, co-authored 78 publications receiving 3802 citations. Previous affiliations of Jacques A. Nunès include French Institute of Health and Medical Research & University of the Mediterranean.
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Journal ArticleDOI
Natural killer cell signaling pathways.
TL;DR: The tyrosine-phosphorylation status of several signaling components that are substrates for both PTKs and PTPs is thus key to the propagation of the NK cell effector pathways.
Journal ArticleDOI
Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling
Françoise Pagès,Marguerite Ragueneau,Robert Rottapel,Robert Rottapel,Alemseged Truneh,Jacques A. Nunès,Jean Imbert,Daniel Olive +7 more
TL;DR: The results suggest that phosphatidylinositol-3-OH kinase is critical for signalling by CD28, and show that CD28 mutants that have their kinase-binding site deleted or the tyrosine at position 173 substituted by phenylalanine do not associate with the kinase after CD28 stimulation and cannot stimulate production of interleukin-2.
Journal ArticleDOI
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors
Nicolas F. Delahaye,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Isabelle Martins,Cédric Ménard,Cédric Ménard,Stephan Roux,Stephan Roux,Luc Lyonnet,Pascale Paul,Matthieu Sarabi,Matthieu Sarabi,Nathalie Chaput,Nathalie Chaput,Michaela Semeraro,Michaela Semeraro,Véronique Minard-Colin,Véronique Minard-Colin,Vichnou Poirier-Colame,Kariman Chaba,Kariman Chaba,Caroline Flament,Caroline Flament,Véronique Baud,Véronique Baud,Véronique Baud,Hélène Authier,Hélène Authier,Hélène Authier,Saadia Kerdine-Römer,Marc Pallardy,Isabelle Cremer,Isabelle Cremer,Laetitia Peaudecerf,Benedita Rocha,Dominique Valteau-Couanet,Dominique Valteau-Couanet,Javier Celis Gutierrez,Jacques A. Nunès,Frédéric Commo,Frédéric Commo,Sylvie Bonvalot,Nicolas Ibrahim,Philippe Terrier,Paule Opolon,Paule Opolon,Cristina Bottino,Cristina Bottino,Alessandro Moretta,Jan Tavernier,Pascal Rihet,Jean Michel Coindre,Jean-Yves Blay,Nicolas Isambert,Jean Franãois Emile,Eric Vivier,A. Lecesne,Guido Kroemer,Laurence Zitvogel +58 more
TL;DR: The genetically determined NKp30 status predicts the clinical outcomes of individuals with GIST independently from KIT mutation, and predominant expression of the immunosuppressiveNKp30c isoform was associated with reduced survival of subjects.
Journal ArticleDOI
Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation
Rémi Lasserre,Xiao-Jun Guo,Fabien Conchonaud,Fabien Conchonaud,Yannick Hamon,Yannick Hamon,Omar Hawchar,Omar Hawchar,Anne-Marie Bernard,Anne-Marie Bernard,Saïdi M. Soudja,Saïdi M. Soudja,Pierre-François Lenne,Pierre-François Lenne,Hervé Rigneault,Hervé Rigneault,Daniel Olive,Georges Bismuth,Georges Bismuth,Jacques A. Nunès,Bernard Payrastre,Bernard Payrastre,Didier Marguet,Didier Marguet,Hai-Tao He,Hai-Tao He +25 more
TL;DR: It is reported here that highly dynamic nanodomains exist in both the outer and inner leaflets of the plasma membrane and it is demonstrated that rafts are critically involved in the activation of a signaling axis that is essential for cell physiology.
Journal ArticleDOI
IFN-α Skews Monocyte Differentiation into Toll-Like Receptor 7-Expressing Dendritic Cells with Potent Functional Activities
Mohamad Mohty,Alexandra Vialle-Castellano,Jacques A. Nunès,Daniel Isnardon,Daniel Olive,Béatrice Gaugler +5 more
TL;DR: The critical role of IFN-α at the early steps of immune response to pathogens or in autoimmune diseases is illustrated by the results of this study, which shows that monocytes cultured in the presence of GM-CSF and IFn-α can differentiate into DCs.