J
Jacques Côté
Researcher at Laval University
Publications - 160
Citations - 21037
Jacques Côté is an academic researcher from Laval University. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 66, co-authored 149 publications receiving 19330 citations. Previous affiliations of Jacques Côté include Howard Hughes Medical Institute & Pennsylvania State University.
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Journal ArticleDOI
Differential remodeling of the HIV-1 nucleosome upon transcription activators and SWI/SNF complex binding.
TL;DR: A different in vitro remodeling of the HIV-1 nucleosome upon the binding of multiple transcription activators and of SWI/SNF complex is demonstrated.
Journal ArticleDOI
Structure/Function Analysis of the Phosphatidylinositol-3-Kinase Domain of Yeast Tra1
A. Irina Mutiu,Stephen M. T. Hoke,Julie Genereaux,Carol Hannam,Katherine MacKenzie,Olivier Jobin-Robitaille,Julie Guzzo,Jacques Côté,Brenda J. Andrews,David B. Haniford,Christopher J. Brandl +10 more
TL;DR: Tra1 is an essential component of the Saccharomyces cerevisiae SAGA and NuA4 complexes and residues within its C-terminal phosphatidylinositol-3-kinase (PI3K) domain that are required for function are identified.
Book ChapterDOI
Functions of myst family histone acetyltransferases and their link to disease.
Nikita Avvakumov,Jacques Côté +1 more
TL;DR: This chapter summarizes the current knowledge on MYST HAT complexes, their functions and link to human diseases.
Journal ArticleDOI
Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase.
Nobuo Horikoshi,Nobuo Horikoshi,Dharmendra Sharma,Fransisca Leonard,Raj K. Pandita,Vijaya Kumar Charaka,Shashank Hambarde,Nobuko T. Horikoshi,Puja G. Khaitan,Puja G. Khaitan,Sharmistha Chakraborty,Jacques Côté,Biana Godin,Clayton R. Hunt,Tej K. Pandita +14 more
TL;DR: The use of CRISPR/Cas9 to introduce I-SceI sites, or repair pathway reporter cassettes, at defined locations within gene-rich and gene-poor regions in human cell lines shows that the frequency of double-stranded break repair by homologous recombination is higher in gene- rich regions with high levels of H4K16ac marks.
Journal ArticleDOI
Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation
Assala Lamaa,Jonathan Humbert,Marion Aguirrebengoa,Xue Cheng,Estelle Nicolas,Jacques Côté,Didier Trouche +6 more
TL;DR: The H2A.Z.Z histone variant plays major roles in the control of gene expression and an integrated analysis of their functions in gene expression using endogenously-tagged proteins showed that they can regulate both distinct and overlapping sets of genes positively or negatively in a context-dependent manner.