J
Jacques Côté
Researcher at Laval University
Publications - 160
Citations - 21037
Jacques Côté is an academic researcher from Laval University. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 66, co-authored 149 publications receiving 19330 citations. Previous affiliations of Jacques Côté include Howard Hughes Medical Institute & Pennsylvania State University.
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Journal ArticleDOI
Eaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis
Xue Cheng,Andréanne Auger,Mohammed Altaf,Simon Drouin,Eric Paquet,Rhea T. Utley,François Robert,Jacques Côté +7 more
TL;DR: Detailed molecular events depict a specific case of cross talk between NuA4-dependent acetylation and incorporation of histone variant Htz1, presetting the chromatin structure over ADE promoters for subsequent chromatin remodeling and activated transcription.
Journal ArticleDOI
Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping.
TL;DR: A role for Rad9 chromatin association, during mitosis, in the DNA damage checkpoint response to telomere uncapping is identified, suggesting that chromatin binding may be an initiating event for checkpoints throughout the cell cycle.
Journal ArticleDOI
NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis
Tomasz Bieluszewski,Weronika Sura,Wojciech Dziegielewski,Anna Bieluszewska,Catherine Lachance,Michal Kabza,Maja Szymanska-Lejman,Mateusz Abram,Piotr Wlodzimierz,Nancy De Winne,Geert De Jaeger,Jan Sadowski,Jacques Côté,Piotr Ziółkowski +13 more
TL;DR: In this article , the authors describe Arabidopsis homologs of the NuA4 scaffold proteins Enhancer of Polycomb-Like 1 (AtEPL1) and Esa1-Associated Factor 1 (EAF1).
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Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin.
Brianna J. Klein,Khan L. Cox,Suk Min Jang,Jacques Côté,Michael G. Poirier,Tatiana G. Kutateladze +5 more
TL;DR: It is found that although both interactions of BRPF1PZP with the H3 tail and DNA are required for tight binding to NCP and for acetyltransferase function of theBRPF1-MORF-ING5-MEAF6 complex, binding to extranucleosomal DNA dominates.
Journal ArticleDOI
De Novo KAT5 Variants Cause a Syndrome with Recognizable Facial Dysmorphisms, Cerebellar Atrophy, Sleep Disturbance, and Epilepsy.
Jonathan Humbert,Smrithi Salian,Periklis Makrythanasis,Periklis Makrythanasis,Gabrielle Lemire,Justine Rousseau,Sophie Ehresmann,Thomas Garcia,Rami Alasiri,Armand Bottani,Sylviane Hanquinet,Erin Beaver,Jennifer Heeley,Ann C.M. Smith,Seth I. Berger,Stylianos E. Antonarakis,Xiang-Jiao Yang,Jacques Côté,Philippe M. Campeau +18 more
TL;DR: In this paper, three individuals with heterozygous de novo missense variants in KAT5 that affect normally invariant residues, with one at the chromodomain (p.Arg53His) and two at or near the acetyl-CoA binding site (pCys369Ser and p.Ser413Ala).