J
Jacques Côté
Researcher at Laval University
Publications - 160
Citations - 21037
Jacques Côté is an academic researcher from Laval University. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 66, co-authored 149 publications receiving 19330 citations. Previous affiliations of Jacques Côté include Howard Hughes Medical Institute & Pennsylvania State University.
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Book ChapterDOI
[7] Experimental analysis of transcription factor-nucleosome interactions
TL;DR: Advanced techniques to analyze the interactions of an individual or group of factors with nucleosome cores are described and protocols to directly assess the proteins present (factors and histones) in ternary complexes resulting from the binding of transcription factors to nucleosomes are provided.
Journal ArticleDOI
Structural and biophysical characterization of the nucleosome-binding PZP domain
Brianna J. Klein,Khan L. Cox,Suk Min Jang,Rohit Singh,Jacques Côté,Michael G. Poirier,Tatiana G. Kutateladze +6 more
TL;DR: In this article, the core subunit of the MORF acetyltransferase complex BRPF1 contains a unique combination of zinc fingers, including a plant homeodomain (PHD) finger followed by a zinc knuckle and another PHD finger, which together form a PZP domain.
Journal ArticleDOI
The NuA4 transcription activation/histone H4 acetyltransferase complex contains the essential Esa1 protein as the catalytic subunit and the essential ATM-related cofactor Tra1p
Stéphane Allard,Rhea T. Utley,Julie Savard,Astrid Clarke,Patrick A. Grant,Christopher J. Brandl,Lorraine Pillus,Jerry L. Workman,Jacques Côté +8 more
TL;DR: The NuA4 transcription activation/histone H4 acetyltransferase complex contains the essential Esa1 protein as the catalytic subunit and the essential ATM-related cofactor Tra1p to resume Regulation of pre-mRNA splicing by protein.
Journal ArticleDOI
MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain
Dustin C. Becht,Brianna J. Klein,Akinori Kanai,Suk Min Jang,Khan L. Cox,Bing Zhou,Sabrina K. Phanor,Yi Zhang,Ruo-Wen Chen,Christopher C. Ebmeier,Catherine Lachance,Maxime Galloy,Amélie Fradet-Turcotte,Martha L. Bulyk,Yawen Bai,Michael G. Poirier,Jacques Côté,Akihito Yokoyama,Tatiana G. Kutateladze +18 more
TL;DR: In this paper , two structured winged helix (WH) domains, WH1 and WH2, were identified and characterized in MORF and MOZ, and the DNA binding function of WHs was investigated.
Journal ArticleDOI
Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.
Maeva Devoucoux,Victoire Fort,Gabriel Khelifi,Joshua Xu,Nader Alerasool,Maxime Galloy,Nicholas C. Wong,Gaelle Bourriquen,Amélie Fradet-Turcotte,Mikko Taipale,Kristin J Hope,Samer M.I. Hussein,Jacques Côté +12 more
TL;DR: In this article , the authors performed a biochemical and functional characterization comparison to each individual fusion partner, and concluded that the ZMYND11-MBTD1 fusion functions primarily by mistargeting the NuA4/TIP60 complex to the body of genes, altering normal transcription of specific genes, likely driving oncogenesis in part through the Myc regulatory network.