J
Jacques Côté
Researcher at Laval University
Publications - 160
Citations - 21037
Jacques Côté is an academic researcher from Laval University. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 66, co-authored 149 publications receiving 19330 citations. Previous affiliations of Jacques Côté include Howard Hughes Medical Institute & Pennsylvania State University.
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Journal ArticleDOI
Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription.
Guillaume Pelletier,Victor Y. Stefanovsky,Marlène Faubladier,Iwona Hirschler-Laszkiewicz,Julie Savard,Lawrence I. Rothblum,Jacques Côté,Tom Moss,Tom Moss +8 more
TL;DR: CBP activation and Rb suppression of ribosomal transcription by recruitment to UBF are mutually exclusive, regulating in vivo PolI transcription through an acetylation-deacetylation "flip-flop."
Journal ArticleDOI
Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity
Marie-Eve Lalonde,Nikita Avvakumov,Karen C. Glass,France-Hélène Joncas,Nehmé Saksouk,Michael J. Holliday,Eric Paquet,Kezhi Yan,Qiong Tong,Brianna J. Klein,Song Tan,Xiang-Jiao Yang,Tatiana G. Kutateladze,Jacques Côté +13 more
TL;DR: A crucial new role for associated proteins within HAT complexes, previously thought to be intrinsic to the catalytic subunit, is uncovered.
Journal ArticleDOI
The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres
Haiying Zhang,Daniel O. Richardson,Daniel O. Richardson,Douglas N. Roberts,Douglas N. Roberts,Rhea T. Utley,Hediye Erdjument-Bromage,Paul Tempst,Jacques Côté,Bradley R. Cairns,Bradley R. Cairns +10 more
TL;DR: Data indicate that Yaf9 may function in NuA4 and SWR1 complexes to help antagonize silencing near telomeres, and the YEATS domain is required for full YAF9 function.
Journal ArticleDOI
MYST protein acetyltransferase activity requires active site lysine autoacetylation.
Hua Yuan,Dorine Rossetto,Hestia Mellert,Weiwei Dang,Madhusudan Srinivasan,Jamel Johnson,Santosh Hodawadekar,Emily Chen Ding,Kaye Speicher,Nebiyu Abshiru,Rocco Perry,Jiang Wu,Chao Yang,Y. George Zheng,David W. Speicher,Pierre Thibault,Alain Verreault,F. Bradley Johnson,Shelley L. Berger,Rolf Sternglanz,Steven B. McMahon,Jacques Côté,Ronen Marmorstein +22 more
TL;DR: These findings provide an avenue for the autoposttranslational regulation of MYST proteins that is distinct from other acetyltransferases but draws similarities to the phosphoregulation of protein kinases.
Journal ArticleDOI
Precise deposition of histone H2A.Z in chromatin for genome expression and maintenance.
Pierre Billon,Jacques Côté +1 more
TL;DR: Recent findings reassert the importance of the regulated deposition of this histone variant H2A.Z in chromatin which shows its implication in chromosomal structure integrity and parallels a role in DNA damage response.