J
Jacques Côté
Researcher at Laval University
Publications - 160
Citations - 21037
Jacques Côté is an academic researcher from Laval University. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 66, co-authored 149 publications receiving 19330 citations. Previous affiliations of Jacques Côté include Howard Hughes Medical Institute & Pennsylvania State University.
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Journal ArticleDOI
Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation.
Brianna J. Klein,Suk Min Jang,Catherine Lachance,Wenyi Mi,Jie Lyu,Shun Sakuraba,Krzysztof Krajewski,Wesley W. Wang,Simone Sidoli,Jiuyang Liu,Yi Zhang,Xiaolu Wang,Becka M. Warfield,Andrew J. Kueh,Anne K. Voss,Tim Thomas,Benjamin A. Garcia,Wenshe R. Liu,Brian D. Strahl,Hidetoshi Kono,Wei Li,Wei Li,Xiaobing Shi,Jacques Côté,Tatiana G. Kutateladze +24 more
TL;DR: The authors identify the native MORF complex as a histone H3K23-specific acetyltransferase and show that interaction of the MORF subunit with acylated H 3K14 promotes acetylation of H3k23 by this complex to activate transcription.
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Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription.
Leonie Kollenstart,Anton J.L. de Groot,George M.C. Janssen,Xue Cheng,Kees Vreeken,Fabrizio Martino,Jacques Côté,Peter A. van Veelen,Haico van Attikum +8 more
TL;DR: It is shown that crotonylation selectively affects gene transcription in vivo in a manner dependent on Gcn5 and Esa1, and is identified as bona fideCrotonyltransferases that promote crotonyation-dependent transcription.
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Opposite role of yeast ING family members in p53-dependent transcriptional activation.
Amine Nourani,LeAnn J. Howe,Marilyn G. Pray-Grant,Jerry L. Workman,Patrick A. Grant,Jacques Côté +5 more
TL;DR: Analysis of the three ING family members present in yeast suggests that the NuA3 complex can function in gene-specific repression, an unusual role for a histone acetyltransferase complex.
Journal ArticleDOI
Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation
Brianna J. Klein,Uma M. Muthurajan,Marie-Eve Lalonde,Matthew D. Gibson,Forest H. Andrews,Maggie R. D. Hepler,Shinichi Machida,Kezhi Yan,Hitoshi Kurumizaka,Michael G. Poirier,Jacques Côté,Karolin Luger,Tatiana G. Kutateladze +12 more
TL;DR: It is demonstrated that the DNA-binding function of the BRPF1 PZP domain is required for the MOZ-BRPF1-ING5-hEaf6 HAT complex to be recruited to chromatin and to acetylate nucleosomal histones, revealing a novel link between chromatin dynamics and MOz-mediated acetylation.
Journal ArticleDOI
A novel H2A/H4 nucleosomal histone acetyltransferase in Tetrahymena thermophila.
Reiko Ohba,David J. Steger,James E. Brownell,Craig A. Mizzen,Richard G. Cook,Jacques Côté,Jerry L. Workman,C. David Allis +7 more
TL;DR: Together, these data document the importance of this novel HAT activity for transcriptional activation from chromatin templates and suggest that a second catalytic HAT subunit, in addition to p55/Gcn5p, is conserved between yeast and Tetrahymena.