Jae-Yeon Choi

TL;DR: It is shown that ERMES and Gem1 have no direct role in the transport of phosphatidylserine from the ER to mitochondria during the synthesis ofosphatidylethanolamine (PE), as PS to PE conversion is not affected in ERmES or gem1 mutants.

TL;DR: This study demonstrated that T. gondii diverts cholesterol from low‐density lipoproteins for cholesteryl ester synthesis and storage in lipid bodies, and indicated that host lipids govern neutral lipid synthesis in Toxoplasma and that interference with mechanisms of host lipid storage is detrimental to parasite survival in mammalian cells.

TL;DR: Using in vivo and in vitro phospholipid synthesis/transport measurements, it is demonstrated that the pstA1-1 mutant is defective in PtdSer transport between the MAM and mitochondria, providing compelling evidence that interorganelle Ptd Ser traffic is regulated by ubiquitination.

TL;DR: Interestingly, a mutation in the yeast choline-phosphate cytidylyltransferase gene abrogates the complementation by Pfpmt thus demonstrating that Pf pmt activity is directly coupled to the Kennedy pathway for the de novo synthesis of phosphatidylcholine.

TL;DR: The specificity, subcellular location, and topological orientation of this novel enzyme are consistent with a role in the re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during proteinN-glycosylation reactions.