L
Lynn M. Almli
Researcher at Emory University
Publications - 49
Citations - 3643
Lynn M. Almli is an academic researcher from Emory University. The author has contributed to research in topics: Genome-wide association study & DNA methylation. The author has an hindex of 28, co-authored 44 publications receiving 2834 citations.
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Journal ArticleDOI
Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability
Laramie E. Duncan,Andrew Ratanatharathorn,Allison E. Aiello,Lynn M. Almli,Amstadter Ab,Allison E. Ashley-Koch,Dewleen G. Baker,Jean C. Beckham,Laura J. Bierut,Jonathan Ian Bisson,Bekh Bradley,Chia-Yen Chen,Shareefa Dalvie,Lindsay A. Farrer,Sandro Galea,Melanie E. Garrett,Joel Gelernter,Guia Guffanti,Michael A. Hauser,Eric O. Johnson,Ronald C. Kessler,Nathan A. Kimbrel,Nathan A. Kimbrel,Anthony P. King,Nastassja Koen,Nastassja Koen,Henry R. Kranzler,Mark W. Logue,Adam X. Maihofer,Alicia R. Martin,Mark W. Miller,Mark W. Miller,Rajendra A. Morey,Nicole R. Nugent,John P. Rice,Stephan Ripke,Stephan Ripke,Stephan Ripke,Andrea L. Roberts,Nancy L. Saccone,Jordan W. Smoller,Jordan W. Smoller,Dan J. Stein,Dan J. Stein,Murray B. Stein,Murray B. Stein,Jennifer A. Sumner,Monica Uddin,Robert J. Ursano,Derek E. Wildman,Rachel Yehuda,Hongyu Zhao,Mark J. Daly,Mark J. Daly,Israel Liberzon,Kerry J. Ressler,Kerry J. Ressler,Caroline M. Nievergelt,Caroline M. Nievergelt,Karestan C. Koenen,Karestan C. Koenen +60 more
TL;DR: The results demonstrate genetic influences on the development of PTSD, identify shared genetic risk between PTSD and other psychiatric disorders and highlight the importance of multiethnic/racial samples.
Journal ArticleDOI
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
Caroline M. Nievergelt,Caroline M. Nievergelt,Adam X. Maihofer,Adam X. Maihofer,Torsten Klengel,Torsten Klengel,Elizabeth G. Atkinson,Elizabeth G. Atkinson,Chia-Yen Chen,Chia-Yen Chen,Karmel W. Choi,Karmel W. Choi,Jonathan R. I. Coleman,Shareefa Dalvie,Laramie E. Duncan,Joel Gelernter,Joel Gelernter,Daniel F. Levey,Daniel F. Levey,Mark W. Logue,Renato Polimanti,Renato Polimanti,Allison C. Provost,Andrew Ratanatharathorn,Murray B. Stein,Murray B. Stein,Katy Torres,Katy Torres,Allison E. Aiello,Lynn M. Almli,Ananda B. Amstadter,Søren Bo Andersen,Ole A. Andreassen,Paul A. Arbisi,Allison E. Ashley-Koch,S. Bryn Austin,Esmina Avdibegović,Dragan Babić,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Dewleen G. Baker,Dewleen G. Baker,Jean C. Beckham,Laura J. Bierut,Jonathan Ian Bisson,Marco P. Boks,Elizabeth A. Bolger,Anders D. Børglum,Anders D. Børglum,Bekh Bradley,Megan Brashear,Gerome Breen,Richard A. Bryant,A.C. Bustamante,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Joseph R. Calabrese,José Miguel Caldas de Almeida,Anders M. Dale,Mark J. Daly,Nikolaos P. Daskalakis,Jürgen Deckert,Douglas L. Delahanty,Michelle F. Dennis,Seth G. Disner,Katharina Domschke,Alma Dzubur-Kulenovic,Christopher R. Erbes,Alexandra Evans,Lindsay A. Farrer,Norah C. Feeny,Janine D. Flory,David Forbes,Carol E. Franz,Sandro Galea,Melanie E. Garrett,Bizu Gelaye,Elbert Geuze,Charles F. Gillespie,Aferdita Goci Uka,Scott D. Gordon,Guia Guffanti,Rasha Hammamieh,Supriya Harnal,Michael A. Hauser,Andrew C. Heath,Sian M. J. Hemmings,David M. Hougaard,David M. Hougaard,Miro Jakovljević,Marti Jett,Eric O. Johnson,Ian Jones,Tanja Jovanovic,Xue Jun Qin,Angela G. Junglen,Karen-Inge Karstoft,Milissa L. Kaufman,Ronald C. Kessler,Alaptagin Khan,Nathan A. Kimbrel,Anthony P. King,Nastassja Koen,Henry R. Kranzler,Henry R. Kranzler,William S. Kremen,William S. Kremen,Bruce R. Lawford,Lauren A.M. Lebois,Catrin Lewis,Sarah D. Linnstaedt,Adriana Lori,Bozo Lugonja,Jurjen J. Luykx,Michael J. Lyons,Jessica L. Maples-Keller,Charles R. Marmar,Alicia R. Martin,Alicia R. Martin,Nicholas G. Martin,Douglas Maurer,Matig R. Mavissakalian,Alexander C. McFarlane,Regina E. McGlinchey,Katie A. McLaughlin,Samuel A. McLean,Sarah McLeay,Divya Mehta,William P. Milberg,Mark W. Miller,Rajendra A. Morey,Charles P. Morris,Ole Mors,Ole Mors,Preben Bo Mortensen,Preben Bo Mortensen,Benjamin M. Neale,Benjamin M. Neale,Elliot C. Nelson,Merete Nordentoft,Merete Nordentoft,Sonya B. Norman,Sonya B. Norman,Meaghan O'Donnell,Holly K. Orcutt,Matthew S. Panizzon,Edward S. Peters,Alan L. Peterson,Matthew Peverill,Robert H. Pietrzak,Robert H. Pietrzak,Melissa A. Polusny,John P. Rice,Stephan Ripke,Stephan Ripke,Stephan Ripke,Victoria B. Risbrough,Victoria B. Risbrough,Andrea L. Roberts,Alex O. Rothbaum,Barbara O. Rothbaum,Peter Roy-Byrne,Kenneth J. Ruggiero,Ariane Rung,Bart P. F. Rutten,Nancy L. Saccone,Sixto E. Sanchez,Dick Schijven,Soraya Seedat,Antonia V. Seligowski,Julia S. Seng,Christina M. Sheerin,Derrick Silove,Alicia K. Smith,Jordan W. Smoller,Jordan W. Smoller,Scott R. Sponheim,Dan J. Stein,Jennifer S. Stevens,Jennifer A. Sumner,Martin H. Teicher,Wesley K. Thompson,Edward J. Trapido,Monica Uddin,Robert J. Ursano,Leigh van den Heuvel,Miranda Van Hooff,Eric Vermetten,Christiaan H. Vinkers,Joanne Voisey,Yunpeng Wang,Yunpeng Wang,Zhewu Wang,Zhewu Wang,Thomas Werge,Thomas Werge,Michelle A. Williams,Douglas E. Williamson,Sherry Winternitz,Christiane Wolf,Erika J. Wolf,Jonathan D. Wolff,Rachel Yehuda,Rachel Yehuda,Ross McD. Young,Keith A. Young,Hongyu Zhao,Lori A. Zoellner,Israel Liberzon,Kerry J. Ressler,Kerry J. Ressler,Magali Haas,Karestan C. Koenen,Karestan C. Koenen +213 more
TL;DR: A GWAS from the Psychiatric Genomics Consortium is reported in which two risk loci in European ancestry and one locus in African ancestry individuals are identified and it is found that PTSD is genetically correlated with several other psychiatric traits.
Journal ArticleDOI
A DNA methylation biomarker of alcohol consumption.
Chunyu Liu,Riccardo E. Marioni,Riccardo E. Marioni,Åsa K. Hedman,Liliane Pfeiffer,P-C Tsai,Lindsay M. Reynolds,Allan C. Just,Qing Duan,Cindy G. Boer,Toshiko Tanaka,Cathy E. Elks,Stella Aslibekyan,Jennifer A. Brody,B. Kuhnel,Christian Herder,Lynn M. Almli,Degui Zhi,Youfa Wang,Tianxiao Huan,Chen Yao,Michael M. Mendelson,Roby Joehanes,Liming Liang,S-A Love,Weihua Guan,Sonia Shah,Allan F. McRae,Axel Kretschmer,Holger Prokisch,Konstantin Strauch,Annette Peters,Peter M. Visscher,Peter M. Visscher,Naomi R. Wray,Xiuqing Guo,Kerri L. Wiggins,A. Smith,Elisabeth B. Binder,Kerry J. Ressler,Marguerite R. Irvin,Devin Absher,Dena G. Hernandez,Luigi Ferrucci,Stefania Bandinelli,Kurt Lohman,Jun Ding,Letizia Trevisi,Stefan Gustafsson,Johanna K. Sandling,Lisette Stolk,André G. Uitterlinden,Idil Yet,Juan E. Castillo-Fernandez,Tim D. Spector,Joel Schwartz,Pantel S. Vokonas,Lars Lind,Yun Li,Myriam Fornage,Donna K. Arnett,Nicholas J. Wareham,Nona Sotoodehnia,Ken K. Ong,J.B. van Meurs,Karen N. Conneely,Andrea A. Baccarelli,Ian J. Deary,Jordana T. Bell,Kari E. North,Yongmei Liu,M. Waldenberger,Stephanie J. London,Erik Ingelsson,Daniel Levy +74 more
TL;DR: An epigenome-wide association study of methylation of cytosine-phosphate-guanine dinucleotide (CpG) sites in relation to alcohol intake identified a robust alcohol-related DNA methylation signature and shown the potential utility ofDNA methylation as a clinically useful diagnostic test to detect current heavy alcohol consumption.
Journal ArticleDOI
Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type
Alicia K. Smith,Varun Kilaru,Mehmet Kocak,Lynn M. Almli,Kristina B. Mercer,Kerry J. Ressler,Kerry J. Ressler,Frances A. Tylavsky,Karen N. Conneely +8 more
TL;DR: Insight is given into how SNPs impact gene regulation and the notion that peripheral blood may be a reliable correlate of physiological processes in other tissues is supported.
Journal ArticleDOI
Accounting for Population Stratification in DNA Methylation Studies
Richard Barfield,Lynn M. Almli,Varun Kilaru,Alicia K. Smith,Kristina B. Mercer,Richard Duncan,Torsten Klengel,Divya Mehta,Elisabeth B. Binder,Michael P. Epstein,Kerry J. Ressler,Karen N. Conneely +11 more
TL;DR: Among the different approaches to computing methylation‐based PCs, it is found that PCs based on CpG sites chosen for their potential to proxy nearby SNPs can provide a powerful and computationally efficient approach to adjust for population stratification in DNA methylation studies when genome‐wide SNP data are unavailable.