J
James S. Goydos
Researcher at Rutgers University
Publications - 90
Citations - 5113
James S. Goydos is an academic researcher from Rutgers University. The author has contributed to research in topics: Melanoma & Metabotropic glutamate receptor 1. The author has an hindex of 36, co-authored 90 publications receiving 4686 citations. Previous affiliations of James S. Goydos include University of Pittsburgh & University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
MDM4 is a key therapeutic target in cutaneous melanoma
Agnieszka Gembarska,Agnieszka Gembarska,Flavie Luciani,Flavie Luciani,Clare G Fedele,Clare G Fedele,Elisabeth A. Russell,Michael Dewaele,Michael Dewaele,Stephanie Villar,Aleksandra Zwolinska,Aleksandra Zwolinska,Sue Haupt,Sue Haupt,Job de Lange,Dana Yip,James S. Goydos,Jody J. Haigh,Ygal Haupt,Ygal Haupt,Ygal Haupt,Lionel Larue,Aart G. Jochemsen,Hubing Shi,Gatien Moriceau,Roger S. Lo,Ghanem Elias Ghanem,Mark Shackleton,Mark Shackleton,Federico Bernal,Jean-Christophe Marine,Jean-Christophe Marine +31 more
TL;DR: It is shown that Mdm4 p53 binding protein homolog (MDM4), a negative regulator of p53, is upregulated in a substantial proportion (∼65%) of stage I–IV human melanomas and that melanocyte-specific MDM4 overexpression enhanced tumorigenesis in a mouse model of melanoma induced by the oncogene Nras.
Journal ArticleDOI
Rewired ERK-JNK Signaling Pathways in Melanoma
Pablo Lopez-Bergami,Pablo Lopez-Bergami,Conway C. Huang,James S. Goydos,Dana Yip,Menashe Bar-Eli,Meenhard Herlyn,Keiran S.M. Smalley,Alka Mahale,Alexey Eroshkin,Stuart A. Aaronson,Ze'ev Ronai +11 more
TL;DR: The data reveal that, in human melanoma, the rewired ERK signaling pathway upregulates JNK and activates the c-Jun oncogene and its downstream targets, including RACK1 and cyclin D1.
Journal ArticleDOI
A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma
TL;DR: In this paper, a 105 amino acid synthetic mucin MUC-1 peptide that has 5 repeated immunodominant epitopes was used to evaluate toxicity and detect mucin-specific immune responses in patients with adenocarcinoma.
Journal ArticleDOI
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia
Pamela M. Pollock,Karine A. Cohen-Solal,Raman Sood,Jin Namkoong,Jeffrey J. Martino,Aruna Koganti,Hua Zhu,Christiane M. Robbins,Izabela Makalowska,Seung Shick Shin,Yarí E. Marín,Kathleen G. Roberts,Laura M. Yudt,Amy Chen,Jun Cheng,Arturo Incao,Heather W. Pinkett,Christopher L. Graham,Karen J. Dunn,Steven M. Crespo-Carbone,Kerine R. Mackason,Kevin Ryan,Daniel Sinsimer,James S. Goydos,Kenneth R. Reuhl,Michael Eckhaus,Paul S. Meltzer,William J. Pavan,Jeffrey M. Trent,Suzie Chen +29 more
TL;DR: This study provides compelling evidence for the importance of metabotropic glutamate signaling in melanocytic neoplasia and detects expression of GRM1 in a number of human melanoma biopsies and cell lines but not in benign nevi and melanocytes.
Journal ArticleDOI
Lessons learned from the Sunbelt Melanoma Trial
Kelly M. McMasters,R. Dirk Noyes,Douglas S. Reintgen,James S. Goydos,Peter D. Beitsch,B. Scott Davidson,Jeffrey J. Sussman,Jeffrey E. Gershenwald,Merrick I. Ross +8 more
TL;DR: A practical definition of sentinel nodes based on the degree of radioactivity is developed and the low rate of postoperative complications associated with SLN biopsy as compared to complete lymph node dissection is established, suggesting that completion lymphadenectomy is appropriate for such patients.