F
Flavie Luciani
Researcher at Katholieke Universiteit Leuven
Publications - 23
Citations - 1641
Flavie Luciani is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Melanoma & Microphthalmia-associated transcription factor. The author has an hindex of 12, co-authored 21 publications receiving 1442 citations. Previous affiliations of Flavie Luciani include Université Paris-Saclay & Curie Institute.
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Journal ArticleDOI
Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state
Annelien Verfaillie,Hana Imrichova,Zeynep Kalender Atak,Michael Dewaele,Florian Rambow,Gert Hulselmans,Valerie Christiaens,Dmitry Svetlichnyy,Flavie Luciani,Laura Van den Mooter,Sofie Claerhout,Mark Fiers,Fabrice Journe,Ghanem Elias Ghanem,Carl Herrmann,Georg Halder,Jean-Christophe Marine,Stein Aerts +17 more
TL;DR: Using regulatory landscapes and in silico analysis, it is shown that transcriptional reprogramming underlies the distinct cellular states present in melanoma and reveals an essential role for the TEADs, linking it to clinically relevant mechanisms such as invasion and resistance.
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β-Catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development
Véronique Delmas,Friedrich Beermann,Silvia Martinozzi,Suzanne Carreira,Julien Ackermann,Mayuko Y. Kumasaka,Laurence Denat,Jane C. Goodall,Flavie Luciani,Amaya Viros,Nese Demirkan,Boris C. Bastian,Colin R. Goding,Lionel Larue +13 more
TL;DR: Stabilized beta-catenin reduces the number of melanoblasts in vivo and immortalizes primary skin melanocytes by silencing the p16(Ink4a) promoter, revealing that synergy between the Wnt and mitogen-activated protein (MAP) kinase pathways may represent an important mechanism underpinning the genesis of melanoma.
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MDM4 is a key therapeutic target in cutaneous melanoma
Agnieszka Gembarska,Agnieszka Gembarska,Flavie Luciani,Flavie Luciani,Clare G Fedele,Clare G Fedele,Elisabeth A. Russell,Michael Dewaele,Michael Dewaele,Stephanie Villar,Aleksandra Zwolinska,Aleksandra Zwolinska,Sue Haupt,Sue Haupt,Job de Lange,Dana Yip,James S. Goydos,Jody J. Haigh,Ygal Haupt,Ygal Haupt,Ygal Haupt,Lionel Larue,Aart G. Jochemsen,Hubing Shi,Gatien Moriceau,Roger S. Lo,Ghanem Elias Ghanem,Mark Shackleton,Mark Shackleton,Federico Bernal,Jean-Christophe Marine,Jean-Christophe Marine +31 more
TL;DR: It is shown that Mdm4 p53 binding protein homolog (MDM4), a negative regulator of p53, is upregulated in a substantial proportion (∼65%) of stage I–IV human melanomas and that melanocyte-specific MDM4 overexpression enhanced tumorigenesis in a mouse model of melanoma induced by the oncogene Nras.
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Stable Overexpression of Smad7 in Human Melanoma Cells Impairs Bone Metastasis
Delphine Javelaud,Khalid S. Mohammad,Christopher McKenna,Pierrick G.J. Fournier,Flavie Luciani,Maryla Niewolna,Jocelyne André,Véronique Delmas,Lionel Larue,Theresa A. Guise,Alain Mauviel,Alain Mauviel +11 more
TL;DR: It is suggested that TGF-beta promotes osteolytic bone metastases due to melanoma by stimulating the expression of prometastatic factors via the Smad pathway and blockade of T GF-beta signaling may be an effective treatment for melanoma metastasis to bone.
Journal ArticleDOI
GLI2-Mediated Melanoma Invasion and Metastasis
Vasileia-Ismini Alexaki,Delphine Javelaud,Delphine Javelaud,Delphine Javelaud,Léon C van Kempen,Khalid S. Mohammad,Sylviane Dennler,Sylviane Dennler,Sylviane Dennler,Flavie Luciani,Flavie Luciani,Keith S. Hoek,Patricia Juárez,James S. Goydos,Pierrick J. Fournier,Claire Sibon,Corine Bertolotto,Franck Verrecchia,Simon Saule,Simon Saule,Véronique Delmas,Véronique Delmas,Robert Ballotti,Lionel Larue,Lionel Larue,Philippe Saiag,Theresa A. Guise,Alain Mauviel,Alain Mauviel,Alain Mauviel +29 more
TL;DR: GLI2 was directly involved in driving melanoma invasion and metastasis in this preclinical study and was identified as a transcriptional target of TGF-beta signaling.