J
Jane Fridlyand
Researcher at Genentech
Publications - 74
Citations - 19991
Jane Fridlyand is an academic researcher from Genentech. The author has contributed to research in topics: Comparative genomic hybridization & Gene. The author has an hindex of 47, co-authored 73 publications receiving 19127 citations. Previous affiliations of Jane Fridlyand include Royal Melbourne Hospital & University of California, San Francisco.
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Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3
Tsui Ting Ching,Alika K. Maunakea,Peter Jun,Chibo Hong,Giuseppe Zardo,Daniel Pinkel,Donna G. Albertson,Jane Fridlyand,Jian-Hua Mao,Ksenya Shchors,William A. Weiss,Joseph F. Costello +11 more
TL;DR: A method for high-resolution analysis of the methylation status of CpG islands genome-wide, using arrays of BAC clones and themethylation-sensitive restriction enzyme NotI is developed, demonstrating the accuracy and specificity of the method.
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Reversing HOXA9 Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma
Bruno M. Costa,Bruno M. Costa,Justin S. Smith,Ying Chen,Justin Chen,Heidi S. Phillips,Kenneth Aldape,Giuseppe Zardo,Giuseppe Zardo,Janice M. Nigro,C. David James,Jane Fridlyand,Rui Manuel Reis,Joseph F. Costello +13 more
TL;DR: In this paper, HOXA9 activation was investigated using reverse transcription-PCR in primary gliomas and glioblastoma cell lines and was validated in two sets of expression array data.
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Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.
Paul A. Reynolds,Mahvash Sigaroudinia,Giuseppe Zardo,Matthew B. Wilson,Geoffrey M. Benton,Caroline J. Miller,Chibo Hong,Jane Fridlyand,Joseph F. Costello,Thea D. Tlsty +9 more
TL;DR: The results demonstrate a causal role of p16INK4A disruption in modulating DNA hypermethylation, and identify a dynamic and active process whereby epigenetic modulation of gene expression is activated as an early event in breast tumor progression.
Journal ArticleDOI
Protein biomarker identification in the CSF of patients with CNS lymphoma.
Sushmita Roy,S. Andrew Josephson,Jane Fridlyand,Jon Karch,Cigall Kadoch,Juliana Karrim,Lloyd E. Damon,Patrick A. Treseler,Sandeep Kunwar,Marc A. Shuman,Ted Jones,Christopher H. Becker,Howard Schulman,James L. Rubenstein +13 more
TL;DR: It is proposed that the discovery of CSF protein biomarkers will facilitate early and noninvasive diagnosis in patients with lesions not amenable to brain biopsy, as well as provide improved surrogates of prognosis and treatment response in CNS lymphoma and brain metastasis.