J
Jane Fridlyand
Researcher at Genentech
Publications - 74
Citations - 19991
Jane Fridlyand is an academic researcher from Genentech. The author has contributed to research in topics: Comparative genomic hybridization & Gene. The author has an hindex of 47, co-authored 73 publications receiving 19127 citations. Previous affiliations of Jane Fridlyand include Royal Melbourne Hospital & University of California, San Francisco.
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Journal ArticleDOI
Shaping of tumor and drug-resistant genomes by instability and selection.
Antoine M. Snijders,Jane Fridlyand,Dorus A Mans,Richard Segraves,Ajay N. Jain,Daniel Pinkel,Donna G. Albertson +6 more
TL;DR: The concept that tumor genomes are shaped by selection for alterations that promote survival and growth advantage, as well as by the particular dysfunctions in genes responsible for maintenance of genetic integrity, is supported.
Journal ArticleDOI
Deletion of chromosome 11q predicts response to anthracycline-based chemotherapy in early breast cancer.
Joan Climent,Joan Climent,Joan Climent,Peter Dimitrow,Jane Fridlyand,José Palacios,Reiner Siebert,Donna G. Albertson,Joe W. Gray,Joe W. Gray,Daniel Pinkel,Ana Lluch,Jose A. Martinez-Climent +12 more
TL;DR: The data suggests that patients with NNBC with the 11q deletion might benefit from anthracycline-based chemotherapy despite other clinical, pathologic, or genetic features, however, these initial findings should be evaluated in randomized clinical trials.
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High-Resolution Analysis of Paraffin-Embedded and Formalin-Fixed Prostate Tumors Using Comparative Genomic Hybridization to Genomic Microarrays
Pamela L. Paris,Donna G. Albertson,Janneke C. Alers,Armann Andaya,Peter R. Carroll,Jane Fridlyand,Ajay N. Jain,Sherwin Kamkar,David Kowbel,Pieter-Jaap Krijtenburg,Daniel Pinkel,Fritz H. Schröder,Kees J. Vissers,Vivienne J. E. Watson,Mark F. Wildhagen,Colin Collins,Herman van Dekken +16 more
TL;DR: In this paper, the authors used archival prostate cancer data for array comparative genomic hybridization with a 2400 element BAC array that provides high-resolution detection of both deletions and amplifications.
Journal ArticleDOI
Chromosomal aberrations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma unspecified: A matrix-based CGH approach
Christoph Thorns,Boris C. Bastian,Daniel Pinkel,Ritu Roydasgupta,Jane Fridlyand,Hartmut Merz,Manuela Krokowski,Heinz-Wolfram Bernd,Alfred C. Feller +8 more
TL;DR: In this paper, the authors used array-based comparative genomic hybridization (CGH) to study genetic imbalances in 39 Angioimmunoblastic T-cell lymphoma (AILT) and 20 PTCL-u.
Journal ArticleDOI
Mapping segmental and sequence variations among laboratory mice using BAC array CGH.
Antoine M. Snijders,Norma J. Nowak,Bing Huey,Jane Fridlyand,Sindy Law,Jeffrey M. Conroy,Taku Tokuyasu,Kubilay Demir,Readman Chiu,Jian-Hua Mao,Ajay N. Jain,Steven J.M. Jones,Allan Balmain,Daniel Pinkel,Donna G. Albertson +14 more
TL;DR: It is shown that small ratio changes distinguish homozygous and heterozygous regions of the genome in interspecific backcross mice, providing an efficient method for genotyping progeny of backcrosses.