R
Rodney R. Higgins
Researcher at Abbott Northwestern Hospital
Publications - 18
Citations - 2681
Rodney R. Higgins is an academic researcher from Abbott Northwestern Hospital. The author has contributed to research in topics: Trisomy & Monosomy. The author has an hindex of 11, co-authored 18 publications receiving 2422 citations.
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Journal ArticleDOI
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
Jay P. Patel,Mithat Gonen,Maria E. Figueroa,Hugo Fernandez,Zhuoxin Sun,Janis Racevskis,Pieter Van Vlierberghe,Igor Dolgalev,Sabrena Thomas,Olga Aminova,Kety Huberman,Janice Cheng,Agnes Viale,Nicholas D. Socci,Adriana Heguy,Athena M. Cherry,Gail H. Vance,Rodney R. Higgins,Rhett P. Ketterling,Robert E. Gallagher,Mark R. Litzow,Marcel R.M. van den Brink,Hillard M. Lazarus,Jacob M. Rowe,Selina M. Luger,Adolfo A. Ferrando,Elisabeth Paietta,Martin S. Tallman,Ari Melnick,Omar Abdel-Wahab,Ross L. Levine +30 more
TL;DR: Genetic predictors of outcome that improved risk stratification among patients with AML, independently of age, white-cell count, induction dose, and post-remission therapy, are identified and the significance of these predictors in an independent cohort is validated.
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Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
Anthony V. Moorman,Christine J. Harrison,Georgina Buck,Sue Richards,Lorna M. Secker-Walker,M Martineau,Gail H. Vance,Athena M. Cherry,Rodney R. Higgins,Adele K. Fielding,Letizia Foroni,Elisabeth Paietta,Martin S. Tallman,Mark R. Litzow,Peter H. Wiernik,Jacob M. Rowe,Anthony H. Goldstone,Gordon W. Dewald +17 more
TL;DR: The observation that Ho-Tr and, for the first time, karyotype complexity confer an increased risk of treatment failure demonstrates that cytogenetic subgroups other than the Ph chromosome can and should be used to risk stratify adults with ALL in future trials.
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Comparison of interphase FISH and metaphase cytogenetics to study myelodysplastic syndrome: an Eastern Cooperative Oncology Group (ECOG) study
Athena M. Cherry,Stephanie R. Brockman,Sarah F. Paternoster,Gary A. Hicks,Donna Neuberg,Rodney R. Higgins,John M. Bennett,Peter L. Greenberg,Peter L. Greenberg,Kenneth B. Miller,Martin S. Tallman,Jacob M. Rowe,Gordon W. Dewald +12 more
TL;DR: It appears that interphase FISH studies are nearly as sensitive as cytogenetic analyses and can be a useful tool in studying bone marrow aspirates where cytogenetics analysis is not possible.
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A multicenter investigation with interphase fluorescence in situ hybridization using X- and Y-chromosome probes.
Gordon W. Dewald,Richard Stallard,A. A.I. Saadi,Susan Arnold,Patricia I. Bader,Ruthann Blough,Kathy Chen,B. Rafael Elejalde,Catherine J. Harris,Rodney R. Higgins,Gerald A. Hoeltge,Wei Tong Hsu,Virginia Kubic,D. James McCorquodale,Mark A. Micale,J. W. Moore,Rosalie M. Phillips,Susan Scheib-Wixted,Stuart Schwartz,Steven Siembieda,Kathy Strole,Peter vanTuinen,Gail H. Vance,Ann Wiktor,Laura Wise,Jar Fee Yung,Julie Zenger-Hain,Alan R. Zinsmeister +27 more
TL;DR: This study indicates that multiple laboratories can test/develop guidelines for the rapid, efficacious, and cost-effective integration of FISH into clinical service.
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FLT3 mutations at diagnosis and relapse in acute myeloid leukemia: cytogenetic and pathologic correlations, including cuplike blast morphology.
Stanley R. McCormick,Matthew J McCormick,Patricia S. Grutkoski,Gregory S. Ducker,Nilanjana Banerji,Rodney R. Higgins,John R. Mendiola,John J Reinartz +7 more
TL;DR: In addition to well-known correlates in pretreatment specimens, FLT3 mutation status has pathologic and cytogenetic significance at relapse and a shift to cuplike blast morphology at relapse may herald emergence of a previously undetectedFLT3/ITD mutation.