M
Matthew E. Merritt
Researcher at University of Florida
Publications - 127
Citations - 5673
Matthew E. Merritt is an academic researcher from University of Florida. The author has contributed to research in topics: Citric acid cycle & Hyperpolarization (physics). The author has an hindex of 37, co-authored 123 publications receiving 4894 citations. Previous affiliations of Matthew E. Merritt include University of Texas Southwestern Medical Center & University of Texas at Dallas.
Papers
More filters
Journal ArticleDOI
Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport
Chendong Yang,Bookyung Ko,Christopher T. Hensley,Lei Jiang,Ajla T. Wasti,Jiyeon Kim,Jessica Sudderth,MariaAntonietta Calvaruso,Lloyd Lumata,Matthew A. Mitsche,Jared Rutter,Matthew E. Merritt,Ralph J. DeBerardinis +12 more
TL;DR: This work shows that import of pyruvate into the mitochondria suppresses GDH and glutamine-dependent acetyl-CoA formation and defines a mechanism to induce glutaminolysis and uncover a survival pathway engaged during compromised supply of pyRuvate to the mitochondaria.
Journal ArticleDOI
PARACEST agents: modulating MRI contrast via water proton exchange
TL;DR: The goal of this article is to review the factors that govern water molecule and water proton exchange in gadolinium (III) complexes and to compare the potential sensitivity of PARACEST agents versus Gd(3+)-based T(1) relaxation agents for altering tissue contrast.
Journal ArticleDOI
Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI
TL;DR: A theoretical framework based on the modified Bloch equations that relates the chemical properties of a CEST agent and various NMR parameters to the measured CEST effect was formulated, and results were in excellent agreement with experimental Z‐spectra obtained with an aqueous solution of a paramagnetic CESTAgent containing two different types of bound protons.
Journal ArticleDOI
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver
Santhosh Satapati,Blanka Kucejova,Joao A.G. Duarte,Justin A. Fletcher,Lacy Reynolds,Nishanth E. Sunny,TianTeng He,L. Arya Nair,Kenneth A. Livingston,Xiaorong Fu,Matthew E. Merritt,A. Dean Sherry,Craig R. Malloy,John M. Shelton,Jennifer E Lambert,Elizabeth J. Parks,Ian R. Corbin,Mark A. Magnuson,Jeffrey D. Browning,Shawn C. Burgess +19 more
TL;DR: Several lines of evidence are provided indicating that induction of biosynthesis through hepatic anaplerotic/cataplerotic pathways is energetically backed by elevated oxidative metabolism and hence contributes to oxidative stress and inflammation during NAFLD.
Journal ArticleDOI
Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology
John Kurhanewicz,Daniel B. Vigneron,Jan Henrik Ardenkjær-Larsen,James A. Bankson,Kevin M. Brindle,Charles H. Cunningham,Ferdia A. Gallagher,Kayvan R. Keshari,Andreas Kjaer,Christoffer Laustsen,David A. Mankoff,Matthew E. Merritt,Sarah J. Nelson,John M. Pauly,Philip Lee,Sabrina M. Ronen,Damian J. Tyler,Sunder S. Rajan,Daniel M. Spielman,Lawrence L. Wald,Xiaoliang Zhang,Craig R. Malloy,Rahim R. Rizi +22 more
TL;DR: Prospects for advancing hyperpolarization technology to better understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13C magnetic resonance imaging’s (MRI) widespread clinical use, and provide recommendations for overcoming them are discussed.