Jarkko Soronen

TL;DR: In rats, the heart-specific VEGF-B transgene induced impressive growth of the epicardial coronary vessels and their branches, with large arteries also seen deep inside the subendocardial myocardium, however, VEGf-B, unlike other V EGF family members, did not induce significant capillary angiogenesis, increased permeability, or inflammatory cell recruitment.

TL;DR: It is concluded that long-term expression of VEGF-C and V EGF-D in skeletal muscle results in the generation of new functional blood and lymphatic vessels.

TL;DR: Overexpression of ANGPTL8 in CHO cells did not result in its release into culture medium while abundant secretion occurred in cells co-expressing AngPTL3 and -8, and measurement of plasma ANGPTl3 but not -8 reflects insulin action in target tissues.

TL;DR: In this article, the authors compared acute in vivo effects of insulin on adipose tissue transcriptional profiles between obese insulin-resistant and lean insulin-sensitive women and found that the most prominent difference in gene expression of the insulin resistant group during hyperinsulinemia was reduced transcription of nuclear genes involved in mitochondrial respiration (mitochondrial respiratory chain, GO:0001934).

TL;DR: By inactivating USF1 in mice, protection against diet-induced dyslipidemia, obesity, insulin resistance, hepatic steatosis, and atherosclerosis is demonstrated and the potential of USf1 as a therapeutic target for cardiometabolic disease is pointed to.