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Alessandra Rustighi
Researcher at University of Trieste
Publications - 14
Citations - 1153
Alessandra Rustighi is an academic researcher from University of Trieste. The author has contributed to research in topics: Notch signaling pathway & HMGA. The author has an hindex of 14, co-authored 14 publications receiving 1055 citations. Previous affiliations of Alessandra Rustighi include University College London & AREA Science Park.
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Journal ArticleDOI
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
Javier E. Girardini,Javier E. Girardini,Marco Napoli,Marco Napoli,Silvano Piazza,Alessandra Rustighi,Alessandra Rustighi,Carolina Marotta,Carolina Marotta,Enrico Radaelli,Valeria Capaci,Valeria Capaci,Lee B. Jordan,Phil Quinlan,Alastair M. Thompson,Alastair M. Thompson,Miguel Mano,Antonio Rosato,Tim Crook,Eugenio Scanziani,Anthony R. Means,Guillermina Lozano,Claudio Schneider,Claudio Schneider,Giannino Del Sal,Giannino Del Sal +25 more
TL;DR: A Pin1/mutant p53 axis that conveys oncogenic signals to promote aggressiveness in human cancers is defined and a transcriptional signature associated with poor prognosis in breast cancer and Pin1 overexpression influenced the prognostic value of p53 mutation is identified.
Journal ArticleDOI
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer
Riccardo Sgarra,Alessandra Rustighi,Michela A. Tessari,Julie Di Bernardo,Sandro Altamura,Alfredo Fusco,Guidalberto Manfioletti,Vincenzo Giancotti +7 more
TL;DR: The structural characteristics of the three nuclear phosphoproteins of the high mobility group A family are outlined and related to their participation in chromatin structure alteration in many biological processes such as gene expression, neoplastic transformation, differentiation, and apoptosis are outlined.
Journal ArticleDOI
Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2.
Michela A. Tessari,Monica Gostissa,Sandro Altamura,Riccardo Sgarra,Alessandra Rustighi,Clio Salvagno,Giuseppina Caretti,Carol Imbriano,Roberto Mantovani,Giannino Del Sal,Giannino Del Sal,Vincenzo Giancotti,Guidalberto Manfioletti +12 more
TL;DR: It is shown that HMGA2 associates with the E1A-regulated transcriptional repressor p120E4F, interfering with p120 E4F binding to the cyclin A promoter, suggesting a mechanism forHMGA2-dependent cell cycle regulation.
Journal ArticleDOI
Prolyl‐isomerase Pin1 controls normal and cancer stem cells of the breast
Alessandra Rustighi,Alessandra Rustighi,Alessandro Zannini,Alessandro Zannini,Luca Tiberi,Luca Tiberi,Roberta Sommaggio,Silvano Piazza,Giovanni Sorrentino,Giovanni Sorrentino,Simona Nuzzo,Antonella Tuscano,Vincenzo Eterno,Federica Benvenuti,Libero Santarpia,Iannis Aifantis,Antonio Rosato,Silvio Bicciato,Alberto Zambelli,Giannino Del Sal,Giannino Del Sal +20 more
TL;DR: In this paper, the prolyl-isomerase Pin1 was shown to be an essential negative regulator of breast CSCs' expansion by restraining Notch activity, but the establishment of a Notch/Pin1 active circuitry opposed this effect, thus promoting breast cancer stem cells self-renewal, tumor growth and metastasis in vivo.
Journal ArticleDOI
Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes
Francesco Paneni,Sarah Costantino,Lorenzo Del Castello,Rodolfo Battista,Giuliana Capretti,Sergio Chiandotto,Domenico D'Amario,Giuseppe Scavone,Angelo Villano,Alessandra Rustighi,Filippo Crea,Dario Pitocco,Gaetano Antonio Lanza,Massimo Volpe,Giannino De Sal,Thomas F. Lüscher,Francesco Cosentino +16 more
TL;DR: Pin1 drives diabetic vascular disease by causing mitochondrial oxidative stress, eNOS dysregulation as well as NF-kB-induced inflammation, and molecular insights for novel mechanism-based therapeutic strategies in patients with diabetes are provided.