Javier González-Miguel

TL;DR: This review is focused on human and animal dirofilariasis, including the basic morphology, biology, protein composition, and metabolism of DiroFilaria species; the climate and human behavioral factors that influence distribution dynamics; the disease pathology; the host-parasite relationship; the mechanisms involved in parasite survival; the immune response and pathogenesis; and the clinical management of human andAnimal infections.

TL;DR: The current prevalence of canine and feline cardiopulmonary dirofilariasis in the European continent, the transmission vectors, the current changes in the distribution and the possible causes are reviewed, though the analysis of the epidemiological studies carried out until 2001 and between 2002 and 2011 are reviewed.

TL;DR: There must be milestones in dirofilariosis research in order to design new strategies and tools for the control of this disease.

TL;DR: Simón et al. as mentioned in this paper reviewed human dirofilariosis in Europe: basic facts and retrospective review and found that the majority of the cases were found in the south-east of Spain.

TL;DR: The data suggest that DiES antigens interact with the environment of the parasite regulating the activation of the fibrinolytic system of the host with involvement of the vascular endothelium in the process.