J
Jean Costentin
Researcher at University of Rouen
Publications - 300
Citations - 13606
Jean Costentin is an academic researcher from University of Rouen. The author has contributed to research in topics: Dopamine & Dopaminergic. The author has an hindex of 51, co-authored 299 publications receiving 13169 citations. Previous affiliations of Jean Costentin include Académie Nationale de Médecine & Centre national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.
Jean-Claude Meunier,Catherine Mollereau,Lawrence Toll,Lawrence Toll,Charles Suaudeau,Christiane Moisand,Paul Alvinerie,Jean-Luc Butour,Jean-Claude Guillemot,Pascual Ferrara,Bernard Monsarrat,Honoré Mazarguil,Gilbert Vassart,Marc Parmentier,Jean Costentin +14 more
TL;DR: Data indicate that the newly discovered heptadecapeptide is an endogenous agonist of the ORL1 receptor and that it may be endowed with pro-nociceptive properties.
Journal ArticleDOI
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.
Catherine Ledent,Jean-Marie Vaugeois,Serge N. Schiffmann,Thierry Pedrazzini,Malika El Yacoubi,Jean-Jacques Vanderhaeghen,Jean Costentin,John K. Heath,Gilbert Vassart,Marc Parmentier +9 more
TL;DR: It was found that A2aR-knockout mice were viable and bred normally, and male mice were much more aggressive towards intruders, whereas caffeine, which normally stimulates exploratory behaviour, became a depressant of exploratory activity.
Journal ArticleDOI
Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions
TL;DR: The simultaneous involvement of D1 and D2 dopamine receptors has been evidenced in the anxiogenic-like effect associated with an increase of dopaminergic transmissions.
Journal ArticleDOI
Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum
TL;DR: It appears that this stereotyped behavior of mice treated with low doses of apomorphine might represent a convenient mean to assess the stimulation of striatal dopamine receptors in mice.
Journal ArticleDOI
The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A2A receptors
Malika El Yacoubi,Catherine Ledent,Jean-François Menard,Marc Parmentier,Jean Costentin,Jean-Marie Vaugeois +5 more
TL;DR: The results suggest that the stimulant effect of low doses of caffeine is mediated by A2A receptor blockade while the depressant effect seen at higher doses under some conditions is explained by A1 receptor blockade.